TY - JOUR
T1 - Disturbed insular functional connectivity and its clinical implication in patients with complex regional pain syndrome
AU - Kim, Jinsol
AU - Namgung, Eun
AU - Lee, Suji
AU - Ha, Eunji
AU - Hong, Haejin
AU - Song, Yumi
AU - Lee, Hyangwon
AU - Oh, Sohyun
AU - Lyoo, In Kyoon
AU - Yoon, Sujung
AU - Jeong, Hyeonseok
N1 - Publisher Copyright:
© 2023
PY - 2023/1
Y1 - 2023/1
N2 - Background: Complex regional pain syndrome (CRPS) is characterized by continued amplification of pain intensity. Given the pivotal roles of the insula in the perception and interpretation of pain, we examined insular functional connectivity and its associations with clinical characteristics in patients with CRPS. Methods: Twenty-one patients with CRPS and 49 healthy controls underwent resting-state functional magnetic resonance imaging. The seed-to-seed functional connectivity analysis was performed for the bilateral insulae and cognitive control regions including the dorsal anterior cingulate cortex (dACC) and bilateral dorsolateral prefrontal cortex (DLPFC) between the two groups. Correlations between altered functional connectivity and clinical characteristics were assessed in CRPS patients. Results: CRPS patients exhibited lower functional connectivity within the bilateral anterior insulae, between the insular and cognitive control regions (the bilateral anterior/posterior insulae-dACC; the right posterior insula-left DLPFC), as compared with healthy controls at false discovery rate-corrected p < 0.05. In CRPS patients, pain severity was associated negatively with the left–right anterior insular functional connectivity (r = −0.49, p = 0.03), yet positively with the left anterior insula-dACC functional connectivity (r = 0.51, p = 0.02). Conclusions: CRPS patients showed lower functional connectivity both within the bilateral anterior insulae and between the insular and cognitive control regions. The current findings may suggest pivotal roles of the insula in dysfunctional pain processing of CRPS patients.
AB - Background: Complex regional pain syndrome (CRPS) is characterized by continued amplification of pain intensity. Given the pivotal roles of the insula in the perception and interpretation of pain, we examined insular functional connectivity and its associations with clinical characteristics in patients with CRPS. Methods: Twenty-one patients with CRPS and 49 healthy controls underwent resting-state functional magnetic resonance imaging. The seed-to-seed functional connectivity analysis was performed for the bilateral insulae and cognitive control regions including the dorsal anterior cingulate cortex (dACC) and bilateral dorsolateral prefrontal cortex (DLPFC) between the two groups. Correlations between altered functional connectivity and clinical characteristics were assessed in CRPS patients. Results: CRPS patients exhibited lower functional connectivity within the bilateral anterior insulae, between the insular and cognitive control regions (the bilateral anterior/posterior insulae-dACC; the right posterior insula-left DLPFC), as compared with healthy controls at false discovery rate-corrected p < 0.05. In CRPS patients, pain severity was associated negatively with the left–right anterior insular functional connectivity (r = −0.49, p = 0.03), yet positively with the left anterior insula-dACC functional connectivity (r = 0.51, p = 0.02). Conclusions: CRPS patients showed lower functional connectivity both within the bilateral anterior insulae and between the insular and cognitive control regions. The current findings may suggest pivotal roles of the insula in dysfunctional pain processing of CRPS patients.
KW - Complex regional pain syndrome
KW - Insula, functional connectivity
KW - Magnetic resonance imaging
UR - https://www.scopus.com/pages/publications/85159828719
U2 - 10.1016/j.nicl.2023.103440
DO - 10.1016/j.nicl.2023.103440
M3 - Article
C2 - 37224606
AN - SCOPUS:85159828719
SN - 2213-1582
VL - 38
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 103440
ER -