Distinct Role of Parvalbumin Expressing Neurons in the Reticular Thalamic Nucleus in Nociception

Sanggeon Park, Jeiwon Cho, Yeowool Huh

Research output: Contribution to journalArticlepeer-review


Loss of inhibition is suggested to cause pathological pain symptoms. Indeed, some human case reports suggest that lesions including the thalamic reticular nucleus (TRN) which provides major inhibitory inputs to other thalamic nuclei, may induce thalamic pain, a type of neuropathic pain. In support, recent studies demonstrated that activation of GABAergic neurons in the TRN reduces nociceptive responses in mice, reiterating the importance of the TRN in gating nociception. However, whether biochemically distinct neuronal types in the TRN differentially contribute to gating nociception has not been investigated. We, therefore, investigated whether the activity of parvalbumin (PV) and somatostatin (SOM) expressing neurons in the somatosensory TRN differentially modulate nociceptive behaviors using optogenetics and immunostaining techniques. We found that activation of PV neurons in the somatosensory TRN significantly reduced nociceptive behaviors, while activation of SOM neurons in the TRN had no such effect. Also, selective activation of PV neurons, but not SOM neurons, in the TRN activated relatively more PV neurons in the primary somatosensory cortex, which delivers inhibitory effect in the cortex, when measured with cFos and PV double staining. Results of our study suggest that PV neurons in the somatosensory TRN have a stronger influence in regulating nociception and that their activations may provide further inhibition in the somatosensory cortex by activating cortical PV neurons.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalExperimental Neurobiology
Issue number6
StatePublished - 31 Dec 2023

Bibliographical note

Publisher Copyright:
© Experimental Neurobiology 2023.


  • Interneurons
  • Mice
  • Optogenetics
  • Parvalbumin
  • Somatostatin
  • Thalamus reticulate nucleus


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