Disrupted white matter tract integrity of anterior cingulate in trauma survivors

Minue J. Kim, In Kyoon Lyoo, Seog Ju Kim, Minyoung Sim, Namkug Kim, Namhee Choi, Do Un Jeong, Julie Covell, Perry F. Renshaw

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


The objective of this study was to examine the integrity of whole-brain white matter in post traumatic stress disorder patients. Twenty posttraumatic stress disorder patients who survived the Taegu subway fire incident and 20 healthy volunteers participated in this study. Statistical parametric mapping was used to evaluate the global differences in fractional anisotropy values between the two groups. The results show that posttraumatic stress disorder patients had significantly lower fractional anisotropy values in the left anterior cingulate regions. Posttraumatic stress disorder symptom severity negatively correlated to the level of decrease in anterior cingulate fractional anisotropy values. The outcome of the current study suggests that the disruption of the left anterior cingulate white matter tract integrity may play an important role in the pathophysiology of posttraumatic stress disorder.

Original languageEnglish
Pages (from-to)1049-1053
Number of pages5
Issue number10
StatePublished - 13 Jul 2005


  • Anterior cingulate
  • Diffusion tensor imaging
  • Posttraumatic stress disorder
  • White matter


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