Discovery of Cyclic Lipopeptides, Octaminomycins C and D, by Engineering LysR Transcriptional Regulator of Streptomyces sp.

Joon Soo An; Jung Min Kim; Jaeho Han; Jun Young Lee; Sang Jip Nam; Sang Kook Lee; Yeo Joon Yoon; Dong Chan Oh

doi:10.1021/acs.jnatprod.4c01047

Discovery of Cyclic Lipopeptides, Octaminomycins C and D, by Engineering LysR Transcriptional Regulator of Streptomyces sp.

Joon Soo An
, Jung Min Kim
, Jaeho Han
, Jun Young Lee
, Sang Jip Nam
, Sang Kook Lee
, Yeo Joon Yoon
, Dong Chan Oh

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

New lipodepsipeptides, octaminomycins C and D (1 and 2), were discovered in an engineered Streptomyces sp. strain overexpressing the LysR transcriptional regulator family. The structures of 1 and 2 were elucidated by comprehensive analysis of their UV, HRMS, and NMR data. The absolute configurations were determined using spectroscopic analysis, the advanced Marfey’s method, and genomic analysis. Genomic analysis enabled the identification of the nonribosomal peptide synthetase (NRPS) biosynthetic pathway of the octaminomycins.

Original language	English
Pages (from-to)	2822-2828
Number of pages	7
Journal	Journal of Natural Products
Volume	87
Issue number	12
DOIs	https://doi.org/10.1021/acs.jnatprod.4c01047
State	Published - 27 Dec 2024

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© 2024 American Chemical Society and American Society of Pharmacognosy.

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title = "Discovery of Cyclic Lipopeptides, Octaminomycins C and D, by Engineering LysR Transcriptional Regulator of Streptomyces sp.",

abstract = "New lipodepsipeptides, octaminomycins C and D (1 and 2), were discovered in an engineered Streptomyces sp. strain overexpressing the LysR transcriptional regulator family. The structures of 1 and 2 were elucidated by comprehensive analysis of their UV, HRMS, and NMR data. The absolute configurations were determined using spectroscopic analysis, the advanced Marfey{\textquoteright}s method, and genomic analysis. Genomic analysis enabled the identification of the nonribosomal peptide synthetase (NRPS) biosynthetic pathway of the octaminomycins.",

author = "An, \{Joon Soo\} and Kim, \{Jung Min\} and Jaeho Han and Lee, \{Jun Young\} and Nam, \{Sang Jip\} and Lee, \{Sang Kook\} and Yoon, \{Yeo Joon\} and Oh, \{Dong Chan\}",

note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society and American Society of Pharmacognosy.",

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month = dec,

day = "27",

doi = "10.1021/acs.jnatprod.4c01047",

language = "English",

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T1 - Discovery of Cyclic Lipopeptides, Octaminomycins C and D, by Engineering LysR Transcriptional Regulator of Streptomyces sp.

AU - An, Joon Soo

AU - Kim, Jung Min

AU - Han, Jaeho

AU - Lee, Jun Young

AU - Nam, Sang Jip

AU - Lee, Sang Kook

AU - Yoon, Yeo Joon

AU - Oh, Dong Chan

PY - 2024/12/27

Y1 - 2024/12/27

N2 - New lipodepsipeptides, octaminomycins C and D (1 and 2), were discovered in an engineered Streptomyces sp. strain overexpressing the LysR transcriptional regulator family. The structures of 1 and 2 were elucidated by comprehensive analysis of their UV, HRMS, and NMR data. The absolute configurations were determined using spectroscopic analysis, the advanced Marfey’s method, and genomic analysis. Genomic analysis enabled the identification of the nonribosomal peptide synthetase (NRPS) biosynthetic pathway of the octaminomycins.

AB - New lipodepsipeptides, octaminomycins C and D (1 and 2), were discovered in an engineered Streptomyces sp. strain overexpressing the LysR transcriptional regulator family. The structures of 1 and 2 were elucidated by comprehensive analysis of their UV, HRMS, and NMR data. The absolute configurations were determined using spectroscopic analysis, the advanced Marfey’s method, and genomic analysis. Genomic analysis enabled the identification of the nonribosomal peptide synthetase (NRPS) biosynthetic pathway of the octaminomycins.

UR - https://www.scopus.com/pages/publications/85212241238

U2 - 10.1021/acs.jnatprod.4c01047

DO - 10.1021/acs.jnatprod.4c01047

M3 - Article

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AN - SCOPUS:85212241238

SN - 0163-3864

VL - 87

SP - 2822

EP - 2828

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 12

ER -

Discovery of Cyclic Lipopeptides, Octaminomycins C and D, by Engineering LysR Transcriptional Regulator of Streptomyces sp.

Abstract

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