Directed assembly of periodic materials from protein and oligonucleotide-modified nanoparticle building blocks

So Jung Park, Anne A. Lazarides, Chad A. Mirkin, Robert L. Letsinger

Research output: Contribution to journalArticlepeer-review

185 Scopus citations

Abstract

DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin (see picture). The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.

Original languageEnglish
Pages (from-to)2909-2912
Number of pages4
JournalAngewandte Chemie - International Edition
Volume40
Issue number15
DOIs
StatePublished - 3 Aug 2001

Keywords

  • DNA structures
  • Nanostructures
  • Oligonucleotides
  • Proteins
  • Small-angle X-ray scattering

Fingerprint

Dive into the research topics of 'Directed assembly of periodic materials from protein and oligonucleotide-modified nanoparticle building blocks'. Together they form a unique fingerprint.

Cite this