Directed assembly of periodic materials from protein and oligonucleotide-modified nanoparticle building blocks

So Jung Park; Anne A. Lazarides; Chad A. Mirkin; Robert L. Letsinger

doi:10.1002/1521-3773(20010803)40:15<2909::AID-ANIE2909>3.0.CO;2-O

Directed assembly of periodic materials from protein and oligonucleotide-modified nanoparticle building blocks

So Jung Park, Anne A. Lazarides, Chad A. Mirkin, Robert L. Letsinger

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Abstract

DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin (see picture). The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.

Original language	English
Pages (from-to)	2909-2912
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	15
DOIs	https://doi.org/10.1002/1521-3773(20010803)40:15<2909::AID-ANIE2909>3.0.CO;2-O
State	Published - 3 Aug 2001

Keywords

DNA structures
Nanostructures
Oligonucleotides
Proteins
Small-angle X-ray scattering

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10.1002/1521-3773(20010803)40:15<2909::AID-ANIE2909>3.0.CO;2-O

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title = "Directed assembly of periodic materials from protein and oligonucleotide-modified nanoparticle building blocks",

abstract = "DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin (see picture). The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.",

keywords = "DNA structures, Nanostructures, Oligonucleotides, Proteins, Small-angle X-ray scattering",

author = "Park, {So Jung} and Lazarides, {Anne A.} and Mirkin, {Chad A.} and Letsinger, {Robert L.}",

year = "2001",

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AU - Lazarides, Anne A.

AU - Mirkin, Chad A.

AU - Letsinger, Robert L.

PY - 2001/8/3

Y1 - 2001/8/3

N2 - DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin (see picture). The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.

AB - DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin (see picture). The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.

KW - DNA structures

KW - Nanostructures

KW - Oligonucleotides

KW - Proteins

KW - Small-angle X-ray scattering

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Directed assembly of periodic materials from protein and oligonucleotide-modified nanoparticle building blocks

Abstract

Keywords

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