Direct observation of radical intermediates while investigating the redox behavior of thiamin coenzyme models

Ikuo Nakanishi; Shinobu Itoh; Tomoyoshi Suenobu; Shunichi Fukuzumi

doi:10.1002/(SICI)1521-3773(19980420)37:7<992::AID-ANIE992>3.0.CO;2-P

Direct observation of radical intermediates while investigating the redox behavior of thiamin coenzyme models

Ikuo Nakanishi
, Shinobu Itoh
, Tomoyoshi Suenobu
, Shunichi Fukuzumi

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The redox behavior of 'active aldehydes' 1- derived from 3-benzylthiazolium salts and simple aldehydes in the presence of a base has been examined with low temperature cyclic voltammetry and EPR spectroscopy. The highly negative oxidation potentials of 1- and the spin distribution of the intermediate radicals 1°indicate that the active aldehyde can act as an efficient electron mediator in thiamin-dependent enzymatic redox systems.

Original language	English
Pages (from-to)	992-994
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	37
Issue number	7
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19980420)37:7<992::AID-ANIE992>3.0.CO;2-P
State	Published - 1998

Keywords

Coenzymes
Cyclic voltammetry
EPR spectroscopy
Radicals
Thiamin

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10.1002/(SICI)1521-3773(19980420)37:7<992::AID-ANIE992>3.0.CO;2-P

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title = "Direct observation of radical intermediates while investigating the redox behavior of thiamin coenzyme models",

abstract = "The redox behavior of 'active aldehydes' 1- derived from 3-benzylthiazolium salts and simple aldehydes in the presence of a base has been examined with low temperature cyclic voltammetry and EPR spectroscopy. The highly negative oxidation potentials of 1- and the spin distribution of the intermediate radicals 1°indicate that the active aldehyde can act as an efficient electron mediator in thiamin-dependent enzymatic redox systems.",

keywords = "Coenzymes, Cyclic voltammetry, EPR spectroscopy, Radicals, Thiamin",

author = "Ikuo Nakanishi and Shinobu Itoh and Tomoyoshi Suenobu and Shunichi Fukuzumi",

year = "1998",

doi = "10.1002/(SICI)1521-3773(19980420)37:7<992::AID-ANIE992>3.0.CO;2-P",

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T1 - Direct observation of radical intermediates while investigating the redox behavior of thiamin coenzyme models

AU - Nakanishi, Ikuo

AU - Itoh, Shinobu

AU - Suenobu, Tomoyoshi

AU - Fukuzumi, Shunichi

PY - 1998

Y1 - 1998

N2 - The redox behavior of 'active aldehydes' 1- derived from 3-benzylthiazolium salts and simple aldehydes in the presence of a base has been examined with low temperature cyclic voltammetry and EPR spectroscopy. The highly negative oxidation potentials of 1- and the spin distribution of the intermediate radicals 1°indicate that the active aldehyde can act as an efficient electron mediator in thiamin-dependent enzymatic redox systems.

AB - The redox behavior of 'active aldehydes' 1- derived from 3-benzylthiazolium salts and simple aldehydes in the presence of a base has been examined with low temperature cyclic voltammetry and EPR spectroscopy. The highly negative oxidation potentials of 1- and the spin distribution of the intermediate radicals 1°indicate that the active aldehyde can act as an efficient electron mediator in thiamin-dependent enzymatic redox systems.

KW - Coenzymes

KW - Cyclic voltammetry

KW - EPR spectroscopy

KW - Radicals

KW - Thiamin

UR - https://www.scopus.com/pages/publications/0031982221

U2 - 10.1002/(SICI)1521-3773(19980420)37:7<992::AID-ANIE992>3.0.CO;2-P

DO - 10.1002/(SICI)1521-3773(19980420)37:7<992::AID-ANIE992>3.0.CO;2-P

M3 - Article

AN - SCOPUS:0031982221

SN - 1433-7851

VL - 37

SP - 992

EP - 994

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 7

ER -

Direct observation of radical intermediates while investigating the redox behavior of thiamin coenzyme models

Abstract

Keywords

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