Direct observation of radical intermediates while investigating the redox behavior of thiamin coenzyme models

Ikuo Nakanishi, Shinobu Itoh, Tomoyoshi Suenobu, Shunichi Fukuzumi

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The redox behavior of 'active aldehydes' 1- derived from 3-benzylthiazolium salts and simple aldehydes in the presence of a base has been examined with low temperature cyclic voltammetry and EPR spectroscopy. The highly negative oxidation potentials of 1- and the spin distribution of the intermediate radicals 1°indicate that the active aldehyde can act as an efficient electron mediator in thiamin-dependent enzymatic redox systems.

Original languageEnglish
Pages (from-to)992-994
Number of pages3
JournalAngewandte Chemie - International Edition
Volume37
Issue number7
DOIs
StatePublished - 1998

Keywords

  • Coenzymes
  • Cyclic voltammetry
  • EPR spectroscopy
  • Radicals
  • Thiamin

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