Direct deposition of anatase TiO2 on thermally unstable gold nanobipyramid: Morphology-conserved plasmonic nanohybrid for combinational photothermal and photocatalytic cancer therapy

Dohyub Jang, Subin Yu, Kyungwha Chung, Jounghyun Yoo, Filipe Marques Mota, Jianfang Wang, Dong June Ahn, Sehoon Kim, Dong Ha Kim

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6 Scopus citations

Abstract

Deposition of crystalline titanium dioxide (TiO2) on gold nanostructures has been considered as a promising strategy for near-infrared (NIR) light-activated photocatalysis. A typical route comprises pre-deposition of amorphous TiO2 on the gold surface and its ensuing crystallization by high-temperature annealing. Such condition, however, is not compatible with highly plasmonic but thermally unstable sharp-tipped gold nanostructures, causing structural disruption and plasmonic decline. Herein, we report a hybridization method excluding high-temperature annealing, i.e., direct deposition of anatase TiO2 onto sharp-tipped gold nanobipyramid (Au NBP/a-TiO2) with conserving their morphology without agglomeration via low-temperature hydrothermal reaction. In addition to keeping the plasmonic photothermal performance, Au NBP/a-TiO2 exhibits enhanced photocatalytic generation of reactive oxygen species in response to the NIR excitation, evidencing the efficient injection of hot electrons from the Au NBP to the anatase shell. In vitro and in vivo studies revealed that the efficient photocatalytic/photothermal responses of Au NBP/a-TiO2, along with dispersion stability in biological media and minimal toxicity, hold potential for synergistic photothermal and photodynamic therapy. We believe that the low-temperature synthetic method introduced here might offer a general way of crystalline deposition of TiO2 on a variety of gold nanostructures, broadening the spectrum of NIR-responsive photocatalytic hybrid nanostructures for biomedical applications.

Original languageEnglish
Article number101472
JournalApplied Materials Today
Volume27
DOIs
StatePublished - Jun 2022

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea Grant funded by the Korean Government (NRF-2020R 1A 2C 3003958), by Basic Science Research Program (Priority Research Institute) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2021R 1A 6A 1A10039823 ), by Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education (2020R 1A 6C 101B194) and by Creative Materials Discovery Program through the NRF of Korea funded by Ministry of Science and ICT (2018M 3D 1A 1058536). The work at Korea Institute of Science and Technology was supported by funds from the National Research Foundation of Korea (2017M3A9D8029942 and 2021R1A2C2005418), and the KIST intramural program. The authors would also like to thank the Korean Basic Science Institute (KBSI) at the Western Seoul center for EPR measurements. This work was supported by the Ewha Womans University Research Grant of 2021.

Publisher Copyright:
© 2022

Keywords

  • Anatase titanium dioxide
  • Gold nanobipyramid
  • Heterojunction structure
  • Near-infrared photocatalysis
  • Photodynamic therapy

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