Dioxygen activation by mononuclear nonheme iron(II) complexes generates iron-oxygen intermediates in the presence of an NADH analogue and proton

Seungwoo Hong, Yong Min Lee, Woonsup Shin, Shunichi Fukuzumi, Wonwoo Nam

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

(Chemical Equation Presented) One primary goal in biomimetic research is to understand mechanisms of dioxygen activation, structures of reactive intermediates, and reactivities of the intermediates involved in catalytic oxidation reactions by metalloenzymes, such as heme and nonheme iron oxygenases. In this communication, we have reported the first example of generating nonheme iron(III)-hydroperoxo and iron(IV)-oxo complexes by activating O2 with a biologically important electron donor, an NADH analogue, and an acid. The formation of iron(III)-hydroperoxo and iron(IV)-oxo complexes was found to depend on the supporting ligands. We have also demonstrated that high-spin nonheme iron(II) complexes with a low oxidation potential are able to bind and activate O2 to generate the iron-oxygen intermediates.

Original languageEnglish
Pages (from-to)13910-13911
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number39
DOIs
StatePublished - 7 Oct 2009

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