Digital breast tomosynthesis and breast ultrasound: Additional roles in dense breasts with category 0 at conventional digital mammography

Won Kyung Lee, Jin Chung, Eun Suk Cha, Jee Eun Lee, Jeoung Hyun Kim

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Purpose To compare the diagnostic performances of digital breast tomosynthesis (DBT) and ultrasound for the dense breasts with category 0 at conventional digital mammography. Materials and methods This retrospective study was approved by the institutional review board, and informed consent was waived. Among the 1103 patients who underwent screening digital mammography at our institution, 769 (69.7%) patients had dense breasts. Of the 769 patients, 229 (29.8%) lesions were categorized as 0. DBT, breast ultrasound and digital mammography were performed in 108 (47.2%) patients. BI-RADS final assessments for DBT and ultrasound were recorded. Categories 1-3 were clinically considered as benign, and categories 4 and 5 were clinically considered as malignant. The diagnostic performances of breast ultrasound and DBT were correlated with final pathologic reports or follow-up images. Results Among 108 lesions, 17 (15.7%) were malignant and 91 (84.3%) were benign. Sensitivity was 100% for both ultrasound (17/17) and DBT (17/17) and negative predictive value was also 100% for both ultrasound (49/49) and DBT (74/74). Specificity and positive predictive value for ultrasound were 53.9% (49/91) and 28.8% (17/59), respectively. Specificity and positive predictive value for DBT were 81.3% (74/91) and 50% (17/34), respectively. DBT showed higher diagnostic accuracy than that of breast ultrasound (DBT: 84.3%, 91/108; ultrasound: 61.1%, 66/108; p <0.001). The benign biopsy rate of DBT (50%, 17/34) was lower than that of ultrasound (71.2%, 42/59). Conclusion DBT showed better diagnostic performance than breast ultrasound for dense breasts with category 0. DBT may reduce the benign biopsy rate and short term follow-up.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalEuropean Journal of Radiology
Volume85
Issue number1
DOIs
StatePublished - 1 Jan 2016

Bibliographical note

Funding Information:
This work was supported by the Ewha Womans University Research Foundation Grant ( 1-2014-1458-001-2 ). Prof. Kyoung Ae Gong from Ewha Womans University kindly provided statistical advice for this manuscript.

Publisher Copyright:
© 2015 Elsevier Ireland Ltd. All rights reserved.

Keywords

  • Breast
  • Dense breast
  • Digital breast tomosynthesis
  • Digital mammography
  • Ultrasound

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