Differentially abundant bacterial taxa associated with prognostic variables of crohnʹs disease: Results from the impact study

Soo Kyung Park, Han Na Kim, Chang Hwan Choi, Jong Pil Im, Jae Myung Cha, Chang Soo Eun, Tae Oh Kim, Sang Bum Kang, Ki Bae Bang, Hyun Gun Kim, Yunho Jung, Hyuk Yoon, Dong-soo-han, Chil Woo Lee, Kwangsung Ahn, Hyung Lae Kim, Dong Il Park

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12 Scopus citations


Limited studies have examined the intestinal microbiota composition in relation to Crohn’s disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing to analyze a cohort of 1110 CD and healthy control (HC) fecal samples. We categorized patients with CD into good (CD-G), intermediate (CD-I) and poor (CD-P) prognosis groups, according to the history of using biologics and intestinal resection. Microbiota α-diversity decreased more in CD-P than CD-G and CD-I. Microbiota ß-diversity in CD-P differed from that in CD-G and CD-I. Thirteen genera and 10 species showed differential abundance between CD-G and CD-P groups. Escherichia coli (p = 0.001) and species Producta (p = 0.01) and genera Lactobacillus (p = 0.003) and Coprococcus (p = 0.01) consistently showed differences between CD-G and CD-P groups after adjusting for confounding variables. Functional profiling suggested that the microbial catabolic pathways and pathways related to enterobacterial common antigen and lipopolysaccharide biosynthesis were better represented in the CD-P group than in the CD-G group, and E. coli were the top contributors to these pathways. CD prognosis is associated with altered microbiota composition and decreased diversity, and E. coli might be causally involved in CD progression, and may have adapted to live in inflammatory environments.

Original languageEnglish
Article number1748
Pages (from-to)1-17
Number of pages17
JournalJournal of Clinical Medicine
Issue number6
StatePublished - Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Crohn’s disease
  • Microbiota
  • Prognosis


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