Differential regional gray matter volumes in patients with on-line game addiction and professional gamers

Doug Hyun Han; In Kyoon Lyoo; Perry F. Renshaw

doi:10.1016/j.jpsychires.2012.01.004

Differential regional gray matter volumes in patients with on-line game addiction and professional gamers

Doug Hyun Han, In Kyoon Lyoo, Perry F. Renshaw

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

Patients with on-line game addiction (POGA) and professional video game players play video games for extended periods of time, but experience very different consequences for their on-line game play. Brain regions consisting of anterior cingulate, thalamus and occpito-temporal areas may increase the likelihood of becoming a pro-gamer or POGA. Twenty POGA, seventeen pro-gamers, and eighteen healthy comparison subjects (HC) were recruited. All magnetic resonance imaging (MRI) was performed on a 1.5 Tesla Espree MRI scanner (SIEMENS, Erlangen, Germany). Voxel-wise comparisons of gray matter volume were performed between the groups using the two-sample t-test with statistical parametric mapping (SPM5). Compared to HC, the POGA group showed increased impulsiveness and perseverative errors, and volume in left thalamus gray matter, but decreased gray matter volume in both inferior temporal gyri, right middle occipital gyrus, and left inferior occipital gyrus, compared with HC. Pro-gamers showed increased gray matter volume in left cingulate gyrus, but decreased gray matter volume in left middle occipital gyrus and right inferior temporal gyrus compared with HC. Additionally, the pro-gamer group showed increased gray matter volume in left cingulate gyrus and decreased left thalamus gray matter volume compared with the POGA group. The current study suggests that increased gray matter volumes of the left cingulate gyrus in pro-gamers and of the left thalamus in POGA may contribute to the different clinical characteristics of pro-gamers and POGA.

Original language	English
Pages (from-to)	507-515
Number of pages	9
Journal	Journal of Psychiatric Research
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/j.jpsychires.2012.01.004
State	Published - Apr 2012

Bibliographical note

Funding Information:
Funding for this study was provided by Korean Game Culture Foundation and NIDA grant (K24DA015116-09); the Korean Game Culture Foundation and NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Funding Information:
This work was supported by Korean Game Culture Foundation and NIDA grant ( K24DA015116-09 ). We thank professional game team, MBC game heroes for providing data and analysis.

Keywords

Cingulate gyrus
Functional magnetic resonance imaging
On-line game addiction
Pro-gamer
Thalamus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jpsychires.2012.01.004

Cite this

@article{795bfb56c0644bf0910145f98e73ddae,

title = "Differential regional gray matter volumes in patients with on-line game addiction and professional gamers",

abstract = "Patients with on-line game addiction (POGA) and professional video game players play video games for extended periods of time, but experience very different consequences for their on-line game play. Brain regions consisting of anterior cingulate, thalamus and occpito-temporal areas may increase the likelihood of becoming a pro-gamer or POGA. Twenty POGA, seventeen pro-gamers, and eighteen healthy comparison subjects (HC) were recruited. All magnetic resonance imaging (MRI) was performed on a 1.5 Tesla Espree MRI scanner (SIEMENS, Erlangen, Germany). Voxel-wise comparisons of gray matter volume were performed between the groups using the two-sample t-test with statistical parametric mapping (SPM5). Compared to HC, the POGA group showed increased impulsiveness and perseverative errors, and volume in left thalamus gray matter, but decreased gray matter volume in both inferior temporal gyri, right middle occipital gyrus, and left inferior occipital gyrus, compared with HC. Pro-gamers showed increased gray matter volume in left cingulate gyrus, but decreased gray matter volume in left middle occipital gyrus and right inferior temporal gyrus compared with HC. Additionally, the pro-gamer group showed increased gray matter volume in left cingulate gyrus and decreased left thalamus gray matter volume compared with the POGA group. The current study suggests that increased gray matter volumes of the left cingulate gyrus in pro-gamers and of the left thalamus in POGA may contribute to the different clinical characteristics of pro-gamers and POGA.",

keywords = "Cingulate gyrus, Functional magnetic resonance imaging, On-line game addiction, Pro-gamer, Thalamus",

author = "Han, {Doug Hyun} and Lyoo, {In Kyoon} and Renshaw, {Perry F.}",

note = "Funding Information: Funding for this study was provided by Korean Game Culture Foundation and NIDA grant (K24DA015116-09); the Korean Game Culture Foundation and NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Funding Information: This work was supported by Korean Game Culture Foundation and NIDA grant ( K24DA015116-09 ). We thank professional game team, MBC game heroes for providing data and analysis.",

year = "2012",

month = apr,

doi = "10.1016/j.jpsychires.2012.01.004",

language = "English",

volume = "46",

pages = "507--515",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier Ltd.",

number = "4",

}

TY - JOUR

T1 - Differential regional gray matter volumes in patients with on-line game addiction and professional gamers

AU - Han, Doug Hyun

AU - Lyoo, In Kyoon

AU - Renshaw, Perry F.

N1 - Funding Information: Funding for this study was provided by Korean Game Culture Foundation and NIDA grant (K24DA015116-09); the Korean Game Culture Foundation and NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Funding Information: This work was supported by Korean Game Culture Foundation and NIDA grant ( K24DA015116-09 ). We thank professional game team, MBC game heroes for providing data and analysis.

PY - 2012/4

Y1 - 2012/4

N2 - Patients with on-line game addiction (POGA) and professional video game players play video games for extended periods of time, but experience very different consequences for their on-line game play. Brain regions consisting of anterior cingulate, thalamus and occpito-temporal areas may increase the likelihood of becoming a pro-gamer or POGA. Twenty POGA, seventeen pro-gamers, and eighteen healthy comparison subjects (HC) were recruited. All magnetic resonance imaging (MRI) was performed on a 1.5 Tesla Espree MRI scanner (SIEMENS, Erlangen, Germany). Voxel-wise comparisons of gray matter volume were performed between the groups using the two-sample t-test with statistical parametric mapping (SPM5). Compared to HC, the POGA group showed increased impulsiveness and perseverative errors, and volume in left thalamus gray matter, but decreased gray matter volume in both inferior temporal gyri, right middle occipital gyrus, and left inferior occipital gyrus, compared with HC. Pro-gamers showed increased gray matter volume in left cingulate gyrus, but decreased gray matter volume in left middle occipital gyrus and right inferior temporal gyrus compared with HC. Additionally, the pro-gamer group showed increased gray matter volume in left cingulate gyrus and decreased left thalamus gray matter volume compared with the POGA group. The current study suggests that increased gray matter volumes of the left cingulate gyrus in pro-gamers and of the left thalamus in POGA may contribute to the different clinical characteristics of pro-gamers and POGA.

AB - Patients with on-line game addiction (POGA) and professional video game players play video games for extended periods of time, but experience very different consequences for their on-line game play. Brain regions consisting of anterior cingulate, thalamus and occpito-temporal areas may increase the likelihood of becoming a pro-gamer or POGA. Twenty POGA, seventeen pro-gamers, and eighteen healthy comparison subjects (HC) were recruited. All magnetic resonance imaging (MRI) was performed on a 1.5 Tesla Espree MRI scanner (SIEMENS, Erlangen, Germany). Voxel-wise comparisons of gray matter volume were performed between the groups using the two-sample t-test with statistical parametric mapping (SPM5). Compared to HC, the POGA group showed increased impulsiveness and perseverative errors, and volume in left thalamus gray matter, but decreased gray matter volume in both inferior temporal gyri, right middle occipital gyrus, and left inferior occipital gyrus, compared with HC. Pro-gamers showed increased gray matter volume in left cingulate gyrus, but decreased gray matter volume in left middle occipital gyrus and right inferior temporal gyrus compared with HC. Additionally, the pro-gamer group showed increased gray matter volume in left cingulate gyrus and decreased left thalamus gray matter volume compared with the POGA group. The current study suggests that increased gray matter volumes of the left cingulate gyrus in pro-gamers and of the left thalamus in POGA may contribute to the different clinical characteristics of pro-gamers and POGA.

KW - Cingulate gyrus

KW - Functional magnetic resonance imaging

KW - On-line game addiction

KW - Pro-gamer

KW - Thalamus

UR - http://www.scopus.com/inward/record.url?scp=84858290152&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychires.2012.01.004

DO - 10.1016/j.jpsychires.2012.01.004

M3 - Article

C2 - 22277302

AN - SCOPUS:84858290152

SN - 0022-3956

VL - 46

SP - 507

EP - 515

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 4

ER -

Differential regional gray matter volumes in patients with on-line game addiction and professional gamers

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this