Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

Ki Bum Won; Hyuk Jae Chang; Hyeon Chang Kim; Kyewon Jeon; Hancheol Lee; Sanghoon Shin; In Jeong Cho; Sung Ha Park; Sang Hak Lee; Yangsoo Jang

doi:10.1186/1475-2840-12-41

Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

Ki Bum Won, Hyuk Jae Chang, Hyeon Chang Kim, Kyewon Jeon, Hancheol Lee, Sanghoon Shin, In Jeong Cho, Sung Ha Park, Sang Hak Lee, Yangsoo Jang

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study.Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.

Original language	English
Article number	41
Journal	Cardiovascular Diabetology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1475-2840-12-41
State	Published - 4 Mar 2013

Bibliographical note

Funding Information:
This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology (2012027176).

Keywords

Atherosclerosis
Diabetes
Metabolic syndrome

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title = "Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes",

abstract = "Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study.Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.",

keywords = "Atherosclerosis, Diabetes, Metabolic syndrome",

author = "Won, {Ki Bum} and Chang, {Hyuk Jae} and Kim, {Hyeon Chang} and Kyewon Jeon and Hancheol Lee and Sanghoon Shin and Cho, {In Jeong} and Park, {Sung Ha} and Lee, {Sang Hak} and Yangsoo Jang",

note = "Funding Information: This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology (2012027176).",

year = "2013",

month = mar,

day = "4",

doi = "10.1186/1475-2840-12-41",

language = "English",

volume = "12",

journal = "Cardiovascular Diabetology",

issn = "1475-2840",

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TY - JOUR

T1 - Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

AU - Won, Ki Bum

AU - Chang, Hyuk Jae

AU - Kim, Hyeon Chang

AU - Jeon, Kyewon

AU - Lee, Hancheol

AU - Shin, Sanghoon

AU - Cho, In Jeong

AU - Park, Sung Ha

AU - Lee, Sang Hak

AU - Jang, Yangsoo

N1 - Funding Information: This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology (2012027176).

PY - 2013/3/4

Y1 - 2013/3/4

N2 - Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study.Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.

AB - Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce.Methods: Surrogate markers of SCA, brachial-ankle pulse wave velocity (baPWV), and carotid intima-medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 ± 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study.Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%); 667 non-diabetics (31%) and 285 diabetics (69%) had MS, respectively. Diabetics had significantly higher baPWV and carotid IMT, and more plaques than non-diabetics (p < 0.001, respectively). Individuals with MS had significantly higher baPWV and carotid IMT than those without MS only among non-diabetics (p < 0.001, respectively). Among MS components, increased blood pressure was significantly associated with the exacerbation of all SCA markers in non-diabetics. The number of MS components was significantly correlated with both baPWV and carotid IMT in non-diabetics (baPWV: r = 0.302, p < 0.001; carotid IMT: r = 0.217, p < 0.001). Multiple regression showed both MS and diabetes were significantly associated with baPWV (p < 0.001, respectively), carotid IMT (MS: p < 0.001; diabetes: p = 0.005), and the presence of plaque (MS: p = 0.041; diabetes: p = 0.002).Conclusions: MS has an incremental impact on SCA in conditions without diabetes. The identification of MS and its individual components is more important for the risk stratification of CVD in non-diabetic individuals.

KW - Atherosclerosis

KW - Diabetes

KW - Metabolic syndrome

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U2 - 10.1186/1475-2840-12-41

DO - 10.1186/1475-2840-12-41

M3 - Article

C2 - 23452437

AN - SCOPUS:84874435007

SN - 1475-2840

VL - 12

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

IS - 1

M1 - 41

ER -

Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes

Abstract

Bibliographical note

Keywords

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