Different therapeutic responses in chronic obstructive pulmonary disease subgroups

J. S. Lee; J. W. Huh; E. J. Chae; J. B. Seo; S. W. Ra; J. H. Lee; E. K. Kim; Y. K. Lee; T. H. Kim; W. J. Kim; J. H. Lee; S. M. Lee; S. Lee; S. Y. Lim; T. R. Shin; H. I. Yoon; S. S. Sheen; Yeon Mok Oh; Sang Do Lee

doi:10.5588/ijtld.10.0553

Different therapeutic responses in chronic obstructive pulmonary disease subgroups

J. S. Lee
, J. W. Huh
, E. J. Chae
, J. B. Seo
, S. W. Ra
, J. H. Lee
, E. K. Kim
, Y. K. Lee
, T. H. Kim
, W. J. Kim
, J. H. Lee
, S. M. Lee
, S. Lee
, S. Y. Lim
, T. R. Shin
, H. I. Yoon
, S. S. Sheen
, Yeon Mok Oh
, Sang Do Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL _CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DL_CO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β₂-agonist (SABA) and 3-month combined inhalation of long-acting β₂-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DL_CO and RV/TLC, 28 (21.5%) low DL_CO and normal RV/TLC, 31 (23.8%) normal DL_CO and high RV/TLC, and 30 (23.1%) low DL_CO and high RV/TLC. The normal DL_CO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DL_CO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DL_CO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DL_CO and RV/TLC may have different pulmonary function responses to pharmacological treatment.

Original language	English
Pages (from-to)	1104-1110
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	15
Issue number	8
DOIs	https://doi.org/10.5588/ijtld.10.0553
State	Published - Aug 2011

Keywords

COPD
Diffusing capacity
Emphysema
Lung volume

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10.5588/ijtld.10.0553

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Lee, J. S., Huh, J. W., Chae, E. J., Seo, J. B., Ra, S. W., Lee, J. H., Kim, E. K., Lee, Y. K., Kim, T. H., Kim, W. J., Lee, J. H., Lee, S. M., Lee, S., Lim, S. Y., Shin, T. R., Yoon, H. I., Sheen, S. S., Oh, Y. M., & Lee, S. D. (2011). Different therapeutic responses in chronic obstructive pulmonary disease subgroups. International Journal of Tuberculosis and Lung Disease, 15(8), 1104-1110. https://doi.org/10.5588/ijtld.10.0553

@article{38e40639ea0d497ca244845241ee6d53,

title = "Different therapeutic responses in chronic obstructive pulmonary disease subgroups",

abstract = "SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β2-agonist (SABA) and 3-month combined inhalation of long-acting β2-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5\%) had normal DLCO and RV/TLC, 28 (21.5\%) low DLCO and normal RV/TLC, 31 (23.8\%) normal DLCO and high RV/TLC, and 30 (23.1\%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLCO and RV/TLC may have different pulmonary function responses to pharmacological treatment.",

keywords = "COPD, Diffusing capacity, Emphysema, Lung volume",

author = "Lee, \{J. S.\} and Huh, \{J. W.\} and Chae, \{E. J.\} and Seo, \{J. B.\} and Ra, \{S. W.\} and Lee, \{J. H.\} and Kim, \{E. K.\} and Lee, \{Y. K.\} and Kim, \{T. H.\} and Kim, \{W. J.\} and Lee, \{J. H.\} and Lee, \{S. M.\} and S. Lee and Lim, \{S. Y.\} and Shin, \{T. R.\} and Yoon, \{H. I.\} and Sheen, \{S. S.\} and Oh, \{Yeon Mok\} and Lee, \{Sang Do\}",

year = "2011",

month = aug,

doi = "10.5588/ijtld.10.0553",

language = "English",

volume = "15",

pages = "1104--1110",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union Against Tuberculosis and Lung Disease ",

number = "8",

}

Lee, JS, Huh, JW, Chae, EJ, Seo, JB, Ra, SW, Lee, JH, Kim, EK, Lee, YK, Kim, TH, Kim, WJ, Lee, JH, Lee, SM, Lee, S, Lim, SY, Shin, TR, Yoon, HI, Sheen, SS, Oh, YM & Lee, SD 2011, 'Different therapeutic responses in chronic obstructive pulmonary disease subgroups', International Journal of Tuberculosis and Lung Disease, vol. 15, no. 8, pp. 1104-1110. https://doi.org/10.5588/ijtld.10.0553

TY - JOUR

T1 - Different therapeutic responses in chronic obstructive pulmonary disease subgroups

AU - Lee, J. S.

AU - Huh, J. W.

AU - Chae, E. J.

AU - Seo, J. B.

AU - Ra, S. W.

AU - Lee, J. H.

AU - Kim, E. K.

AU - Lee, Y. K.

AU - Kim, T. H.

AU - Kim, W. J.

AU - Lee, J. H.

AU - Lee, S. M.

AU - Lee, S.

AU - Lim, S. Y.

AU - Shin, T. R.

AU - Yoon, H. I.

AU - Sheen, S. S.

AU - Oh, Yeon Mok

AU - Lee, Sang Do

PY - 2011/8

Y1 - 2011/8

N2 - SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β2-agonist (SABA) and 3-month combined inhalation of long-acting β2-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DLCO and RV/TLC, 28 (21.5%) low DLCO and normal RV/TLC, 31 (23.8%) normal DLCO and high RV/TLC, and 30 (23.1%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLCO and RV/TLC may have different pulmonary function responses to pharmacological treatment.

AB - SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β2-agonist (SABA) and 3-month combined inhalation of long-acting β2-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DLCO and RV/TLC, 28 (21.5%) low DLCO and normal RV/TLC, 31 (23.8%) normal DLCO and high RV/TLC, and 30 (23.1%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLCO and RV/TLC may have different pulmonary function responses to pharmacological treatment.

KW - COPD

KW - Diffusing capacity

KW - Emphysema

KW - Lung volume

UR - https://www.scopus.com/pages/publications/79960426876

U2 - 10.5588/ijtld.10.0553

DO - 10.5588/ijtld.10.0553

M3 - Article

C2 - 21740676

AN - SCOPUS:79960426876

SN - 1027-3719

VL - 15

SP - 1104

EP - 1110

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 8

ER -

Different therapeutic responses in chronic obstructive pulmonary disease subgroups

Abstract

Keywords

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