Different therapeutic responses in chronic obstructive pulmonary disease subgroups

J. S. Lee; J. W. Huh; E. J. Chae; J. B. Seo; S. W. Ra; J. H. Lee; E. K. Kim; Y. K. Lee; T. H. Kim; W. J. Kim; J. H. Lee; S. M. Lee; S. Lee; S. Y. Lim; T. R. Shin; H. I. Yoon; S. S. Sheen; Yeon Mok Oh; Sang Do Lee

doi:10.5588/ijtld.10.0553

Different therapeutic responses in chronic obstructive pulmonary disease subgroups

J. S. Lee, J. W. Huh, E. J. Chae, J. B. Seo, S. W. Ra, J. H. Lee, E. K. Kim, Y. K. Lee, T. H. Kim, W. J. Kim, J. H. Lee, S. M. Lee, S. Lee, S. Y. Lim, T. R. Shin, H. I. Yoon, S. S. Sheen, Yeon Mok Oh, Sang Do Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL _CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DL_CO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β₂-agonist (SABA) and 3-month combined inhalation of long-acting β₂-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DL_CO and RV/TLC, 28 (21.5%) low DL_CO and normal RV/TLC, 31 (23.8%) normal DL_CO and high RV/TLC, and 30 (23.1%) low DL_CO and high RV/TLC. The normal DL_CO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DL_CO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DL_CO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DL_CO and RV/TLC may have different pulmonary function responses to pharmacological treatment.

Original language	English
Pages (from-to)	1104-1110
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	15
Issue number	8
DOIs	https://doi.org/10.5588/ijtld.10.0553
State	Published - Aug 2011

Keywords

COPD
Diffusing capacity
Emphysema
Lung volume

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10.5588/ijtld.10.0553

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Lee, J. S., Huh, J. W., Chae, E. J., Seo, J. B., Ra, S. W., Lee, J. H., Kim, E. K., Lee, Y. K., Kim, T. H., Kim, W. J., Lee, J. H., Lee, S. M., Lee, S., Lim, S. Y., Shin, T. R., Yoon, H. I., Sheen, S. S., Oh, Y. M., & Lee, S. D. (2011). Different therapeutic responses in chronic obstructive pulmonary disease subgroups. International Journal of Tuberculosis and Lung Disease, 15(8), 1104-1110. https://doi.org/10.5588/ijtld.10.0553

@article{38e40639ea0d497ca244845241ee6d53,

title = "Different therapeutic responses in chronic obstructive pulmonary disease subgroups",

abstract = "SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β2-agonist (SABA) and 3-month combined inhalation of long-acting β2-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DLCO and RV/TLC, 28 (21.5%) low DLCO and normal RV/TLC, 31 (23.8%) normal DLCO and high RV/TLC, and 30 (23.1%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLCO and RV/TLC may have different pulmonary function responses to pharmacological treatment.",

keywords = "COPD, Diffusing capacity, Emphysema, Lung volume",

author = "Lee, {J. S.} and Huh, {J. W.} and Chae, {E. J.} and Seo, {J. B.} and Ra, {S. W.} and Lee, {J. H.} and Kim, {E. K.} and Lee, {Y. K.} and Kim, {T. H.} and Kim, {W. J.} and Lee, {J. H.} and Lee, {S. M.} and S. Lee and Lim, {S. Y.} and Shin, {T. R.} and Yoon, {H. I.} and Sheen, {S. S.} and Oh, {Yeon Mok} and Lee, {Sang Do}",

year = "2011",

month = aug,

doi = "10.5588/ijtld.10.0553",

language = "English",

volume = "15",

pages = "1104--1110",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union Against Tuberculosis and Lung Disease (The Union)",

number = "8",

}

Lee, JS, Huh, JW, Chae, EJ, Seo, JB, Ra, SW, Lee, JH, Kim, EK, Lee, YK, Kim, TH, Kim, WJ, Lee, JH, Lee, SM, Lee, S, Lim, SY, Shin, TR, Yoon, HI, Sheen, SS, Oh, YM & Lee, SD 2011, 'Different therapeutic responses in chronic obstructive pulmonary disease subgroups', International Journal of Tuberculosis and Lung Disease, vol. 15, no. 8, pp. 1104-1110. https://doi.org/10.5588/ijtld.10.0553

TY - JOUR

T1 - Different therapeutic responses in chronic obstructive pulmonary disease subgroups

AU - Lee, J. S.

AU - Huh, J. W.

AU - Chae, E. J.

AU - Seo, J. B.

AU - Ra, S. W.

AU - Lee, J. H.

AU - Kim, E. K.

AU - Lee, Y. K.

AU - Kim, T. H.

AU - Kim, W. J.

AU - Lee, J. H.

AU - Lee, S. M.

AU - Lee, S.

AU - Lim, S. Y.

AU - Shin, T. R.

AU - Yoon, H. I.

AU - Sheen, S. S.

AU - Oh, Yeon Mok

AU - Lee, Sang Do

PY - 2011/8

Y1 - 2011/8

N2 - SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β2-agonist (SABA) and 3-month combined inhalation of long-acting β2-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DLCO and RV/TLC, 28 (21.5%) low DLCO and normal RV/TLC, 31 (23.8%) normal DLCO and high RV/TLC, and 30 (23.1%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLCO and RV/TLC may have different pulmonary function responses to pharmacological treatment.

AB - SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classifi ed by diffusing capacity of the lung for carbon monoxide (DL CO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β2-agonist (SABA) and 3-month combined inhalation of long-acting β2-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DLCO and RV/TLC, 28 (21.5%) low DLCO and normal RV/TLC, 31 (23.8%) normal DLCO and high RV/TLC, and 30 (23.1%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a signifi-cantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLCO and RV/TLC may have different pulmonary function responses to pharmacological treatment.

KW - COPD

KW - Diffusing capacity

KW - Emphysema

KW - Lung volume

UR - http://www.scopus.com/inward/record.url?scp=79960426876&partnerID=8YFLogxK

U2 - 10.5588/ijtld.10.0553

DO - 10.5588/ijtld.10.0553

M3 - Article

C2 - 21740676

AN - SCOPUS:79960426876

SN - 1027-3719

VL - 15

SP - 1104

EP - 1110

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 8

ER -

Different therapeutic responses in chronic obstructive pulmonary disease subgroups

Abstract

Keywords

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