Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction

Jinkwon Kim, Tae Jin Song, Ji Hye Park, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe Heo

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


Objective: We aimed to investigate the relationship of each white blood cells (WBC) subtype with neurologic severity and outcome in acute stroke. Methods: We included 779 patients with first-ever acute cerebral infarction within 72. h after symptom onset. We investigated the association between counts for WBC subtypes in peripheral blood at admission and (1) initial stroke severity; (2) early change in stroke severity within one week; and (3) functional outcome at three months. Results: Higher total WBC and neutrophil counts were associated with more severe stroke at admission (p<0.001). In contrast, lower lymphocyte counts were associated with a lesser improvement during the first week after admission (p<0.05) and with poor functional outcome at three months (OR=0.706 per 1000 lymphocyte counts/mm3, p=0.020). Conclusions: Our study merits further investigation on the role of each WBC subtype in ischemic injury and different prognostic value of WBC subtypes measured at admission in acute stroke.

Original languageEnglish
Pages (from-to)464-467
Number of pages4
Issue number2
StatePublished - Jun 2012

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Healthcare Technology Research and Development Project, Ministry of Health, Welfare, and Family Affairs, Republic of Korea ( A102065 ).


  • Leukocyte
  • Lymphocyte
  • Stroke
  • White blood cell


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