@article{9f1d8d1925e14fba9ab067eb02bc5255,
title = "Different clinical characteristics and impact of carbapenem-resistance on outcomes between Acinetobacter baumannii and Pseudomonas aeruginosa bacteraemia: a prospective observational study",
abstract = "This study aimed to evaluate the differences in clinical characteristics and impact of carbapenem resistance (CR) on outcomes between Acinetobacter baumannii (Ab) and Pseudomonas aeruginosa (Pa) bacteraemia. We prospectively identified all patients with Ab and Pa bacteraemia in 10 hospitals over 1 year. Treatment failure was defined as all-cause 30-day mortality, persistent bacteraemia, or recurrent bacteraemia within 30 days. We included 304 Ab and 241 Pa bacteraemia cases. CR was detected in 216 patients (71%) with Ab bacteraemia and 55 patients (23%) with Pa bacteraemia. Treatment failure was significantly higher in CR-Ab than in CR-Pa (60.6% vs. 34.5%, P = 0.001). In Ab, severe sepsis or septic shock and high Pitt bacteraemia score were independent risk factors for treatment failure in the inappropriate empirical antibiotics group. In Pa, hospital-acquired infection and high Pitt bacteraemia score were independent risk factors for treatment failure in both groups. CR was an independent risk factor in Ab for treatment failure in both groups, but not in Pa bacteraemia. We demonstrated significant differences in clinical characteristics and impact of CR on clinical outcomes between Ab and Pa bacteraemia, suggesting that different treatment approaches may be needed.",
author = "{the Korea INfectious Diseases (KIND) study group} and Lee, {Chan Mi} and Kim, {Young Jun} and Jung, {Sook In} and Kim, {Seong Eun} and Park, {Wan Beom} and Choe, {Pyoeng Gyun} and Kim, {Eu Suk} and Kim, {Chung Jong} and Choi, {Hee Jung} and Shinwon Lee and Lee, {Sun Hee} and Younghee Jung and Bang, {Ji Hwan} and Shinhye Cheon and Kwak, {Yee Gyung} and Kang, {Yu Min} and Park, {Kyung Hwa} and Song, {Kyoung Ho} and Kim, {Hong Bin} and Lee, {Chan Mi} and Kim, {Young Jun} and Jung, {Sook In} and Kim, {Seong Eun} and Kim, {Eu Suk} and Kim, {Chung Jong} and Choi, {Hee Jung} and Shinwon Lee and Lee, {Sun Hee} and Younghee Jung and Bang, {Ji Hwan} and Shinhye Cheon and Kwak, {Yee Gyung} and Kang, {Yu Min} and Park, {Kyung Hwa} and Song, {Kyoung Ho} and Kim, {Hong Bin}",
note = "Funding Information: This work was supported by the Research Program funded by the Korea Disease Control and Prevention Agency (Grant number 2017E280301); the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Grant number 2021R1F1A1063089). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
day = "1",
doi = "10.1038/s41598-022-12482-0",
language = "English",
volume = "12",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}