Dietary wolfberry extract modifies oxidative stress by controlling the expression of inflammatory mrnas in overweight and hypercholesterolemic subjects: A randomized, double-blind, placebo-controlled trial

You Jin Lee, Youngsook Ahn, Oran Kwon, Mee Youn Lee, Choong Hwan Lee, Sungyoung Lee, Taesung Park, Sung Won Kwon, Ji Yeon Kim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

In the present study, we evaluated the antioxidative and anti-inflammatory effects of an aqueous extract of wolfberry fruit (WBE) in mild hypercholesterolemic and overweight subjects. This study was a double-blind randomized trial of two parallel groups of free-living subjects (n = 53). The participants consumed the contents of an 80 mL pouch containing 13.5 g WBE or placebo after one meal per day over an 8-week period. Following 8 weeks of WBE supplementation, we observed a slight but significant decrease in erythrocyte superoxide dismutase activity and an increase in catalase activity. Furthermore, to assess endogenous DNA damage in lymphocytes, the alkaline comet assay was performed, showing that the percentage of DNA in the tail was significantly decreased by 8-week WBE intake. Additionally, the proportion of significantly deregulated mRNAs related to oxidative or inflammatory stress was considerably higher in the WBE intake group. The present data indicate that WBE intake has antioxidative and anti-inflammatory effects in overweight and hypercholesterolemic subjects by modulating mRNA expression.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume65
Issue number2
DOIs
StatePublished - 18 Jan 2017

Keywords

  • DNA damage
  • Inflammation
  • Postprandial inflammatory response
  • Wolfberry fruit extract
  • mRNA array

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