Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression

Goo Taeg Oh, Jae Hoon Choi, Jung Joo Hong, Dae Young Kim, Sae Bom Lee, Ju Ryoung Kim, Chul Ho Lee, Byung Hwa Hyun, Sei Ryang Oh, Song Hae Bok, Tae Sook Jeong

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30 Scopus citations

Abstract

Hematein is a compound isolated from Caesalpinia sappan that has been used in oriental medicine as both an analgesic and an anti-inflammatory agent. In this study, we examined the anti-atherogenic potential of hematein using cholesterol-fed New Zealand White (NZW) rabbits. NZW rabbits were divided into a hematein-supplemented (0.05% in diet) group (n = 6), a probucol-supplemented (0.25% in diet) group (n = 6), and a control group (n = 6). After 8 weeks of treatments, the extent of the atherosclerotic lesions was significantly reduced in the hematein-supplemented group and the probucol-supplemented group without changing plasma lipoprotein levels. Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) expression on the descending aorta induced by cholesterol diet. In culture, hematein also significantly inhibited the secretion of soluble VCAM-1 and of monocyte chemotactic protein-1 (MCP-1) respectively induced by tumor necrotic factor α (TNF-α) and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell (HUVEC) culture. Also, hematein inhibited monocyte adhesion to endothelial cell and the activation of NF-κB in HUVECs stimulated with TNF-α. The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalAtherosclerosis
Volume159
Issue number1
DOIs
StatePublished - 2001

Bibliographical note

Funding Information:
This work was supported by a grant (HMP-98-D-4-0044) from the Ministry of Health and Welfare of KOREA. We acknowledge the technical assistance of Moon Og Sung and Sung-Kyu Kim.

Keywords

  • Atherosclerosis
  • Hematein
  • MCP-1
  • VCAM-1

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