Diagnostic and therapeutic implications of micrornas in non-small cell lung cancer

Young Ho Ahn, Yoon Ho Ko

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

microRNAs (miRNAs), endogenous suppressors of target mRNAs, are deeply involved in every step of non-small cell lung cancer (NSCLC) development, from tumor initiation to progression and metastasis. They play roles in cell proliferation, apoptosis, angiogenesis, epithelial-to-mesenchymal transition, migration, invasion, and metastatic colonization, as well as immunosuppression. Due to their versatility, numerous attempts have been made to use miRNAs for clinical applications. miRNAs can be used as cancer subtype classifiers, diagnostic markers, drug-response predictors, prognostic markers, and therapeutic targets in NSCLC. Many challenges remain ahead of their actual clinical application; however, when achieved, the use of miRNAs in the clinic is expected to enable great progress in the diagnosis and treatment of patients with NSCLC.

Original languageEnglish
Article number8782
Pages (from-to)1-17
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume21
Issue number22
DOIs
StatePublished - 2 Nov 2020

Keywords

  • Diagnosis
  • MicroRNA
  • Non-small cell lung cancer
  • Prognosis

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