Diagnostic and therapeutic implications of micrornas in non-small cell lung cancer

Young Ho Ahn, Yoon Ho Ko

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


microRNAs (miRNAs), endogenous suppressors of target mRNAs, are deeply involved in every step of non-small cell lung cancer (NSCLC) development, from tumor initiation to progression and metastasis. They play roles in cell proliferation, apoptosis, angiogenesis, epithelial-to-mesenchymal transition, migration, invasion, and metastatic colonization, as well as immunosuppression. Due to their versatility, numerous attempts have been made to use miRNAs for clinical applications. miRNAs can be used as cancer subtype classifiers, diagnostic markers, drug-response predictors, prognostic markers, and therapeutic targets in NSCLC. Many challenges remain ahead of their actual clinical application; however, when achieved, the use of miRNAs in the clinic is expected to enable great progress in the diagnosis and treatment of patients with NSCLC.

Original languageEnglish
Article number8782
Pages (from-to)1-17
Number of pages17
JournalInternational Journal of Molecular Sciences
Issue number22
StatePublished - 2 Nov 2020

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2020R1A5A2019210 to Y.-H.A.; 2018R1D1A1A02085738 to Y.H.K.) and by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1720100 to Y.H.K.).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Diagnosis
  • MicroRNA
  • Non-small cell lung cancer
  • Prognosis


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