DhITACT: DNA hydrogel formation by isothermal amplification of complementary target in fluidic channels

Ho Yeon Lee, Hansaem Jeong, Il Young Jung, Bora Jang, Young Chang Seo, Haeshin Lee, Hyukjin Lee

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

DNA hydrogel formation by isothermal amplification of complementary targets in microfluidic channels (DhITACT) is a new platform for rapid and accurate detection of infectious pathogens. DNA hydrogel is formed in situ within microfluidic channels by the isothermal rolling circle amplification process upon the selective binding of target strands from the biological fluid. Once the volume of DNA hydrogel sufficiently enlarges, it can selectively block the matching channels with target pathogens.

Original languageEnglish
Pages (from-to)3513-3517
Number of pages5
JournalAdvanced Materials
Volume27
Issue number23
DOIs
StatePublished - 1 Jun 2015

Keywords

  • DNA hydrogel
  • microfluidic array chip
  • molecular diagnostic platform
  • rolling circle amplification

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