Development of mechanically reinforced bioadhesive electrospun nanofibers using cellulose acetate–levan complexes

Young Hoon Song, Eunhyun Ji, Kye Il Joo, Jeong Hyun Seo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Although electrospun nanofibers have great potential for various tissue engineering applications, owing to their large surface area and extracellular matrix-mimicking properties, their lack of appropriate mechanical strength and biological cues for cell adhesion and proliferation limits their widespread use in tissue engineering. Nanofiber composite possessing two or more desired properties and functions has garnered considerable attention regarding its utility in diverse biomedical applications. In the present study, we aimed to develop a mechanically reinforced electrospun composite nanofiber by blending cellulose acetate and levan. Crosslinking the composite nanofiber with citric acid could significantly enhance its mechanical properties and thermal stability. In fact, the composite nanofibers had an adhesive strength of up to 1.27 MPa, which is similar to that of commercial tissue adhesive fibrin glue. The bioadhesive trait of composite nanofiber and the unique properties of levan not only enabled remarkable biocompatibility but also improved the levels of cell attachment and proliferation. Overall, the developed electrospun composite nanofibers can be used as promising cell scaffolds in tissue regenerative cell therapy.

Original languageEnglish
Pages (from-to)1685-1696
Number of pages12
Issue number3
StatePublished - Feb 2023

Bibliographical note

Funding Information:
This study was supported by the National Research Foundation (NRF) of Korea [Grant Number 2019R1A2C1006747] funded by the Ministry of Science and ICT and Basic Science Research Program funded by the Ministry of Education (Grant Number 2020R1I1A1A01072868).

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature B.V.


  • Bioadhesive
  • Composite nanofiber
  • Crosslinking
  • Electrospinning
  • Levan


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