Development of fluorescent probes based on protection-deprotection of the key functional groups for biological imaging

Yonghe Tang, Dayoung Lee, Jiaoliang Wang, Guanhan Li, Jinghua Yu, Weiying Lin, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

314 Scopus citations

Abstract

Recently, the strategy of protection-deprotection of functional groups has been widely employed to design fluorescent probes, as the protection-deprotection of functional groups often induces a marked change in electronic properties. Significant advances have been made in the development of analyte-responsive fluorescent probes based on the protection-deprotection strategy. In this tutorial review, we highlight the representative examples of small-molecule based fluorescent probes for bioimaging, which are operated via the protection-deprotection of key functional groups such as aldehyde, hydroxyl, and amino functional groups reported from 2010 to 2014. The discussion includes the general protection-deprotection methods for aldehyde, hydroxyl, or amino groups, as well as the design strategies, sensing mechanisms, and deprotection modes of the representative fluorescent imaging probes applied to bio-imaging.

Original languageEnglish
Pages (from-to)5003-5015
Number of pages13
JournalChemical Society Reviews
Volume44
Issue number15
DOIs
StatePublished - 7 Aug 2015

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