TY - JOUR
T1 - Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets
AU - Jeon, So Hyeon
AU - Kim, Yong Pyo
AU - Kho, Younglim
AU - Shin, Jeoung Hwa
AU - Ji, Won Hyun
AU - Ahn, Yun Gyong
N1 - Funding Information:
.is research was supported by the Bio-synergy Research Project (NRF-2017M3A9C4065961) of the Ministry of Science, ICT, and Future Planning through the National
Funding Information:
This research was supported by the Bio-synergy Research Project (NRF-2017M3A9C4065961) of the Ministry of Science, ICT, and Future Planning through the National Research Foundation and Korea Basic Science Institute grant (C37705).
Funding Information:
Research Foundation and Korea Basic Science Institute grant (C37705).
Publisher Copyright:
© 2018 So Hyeon Jeon et al.
PY - 2018
Y1 - 2018
N2 - A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode. Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis. Average recoveries of the eight target analytes are typically in the range of 91.8-122% with the relative standard deviations of 1.8-17.8%. The limits of quantification (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g. Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations.
AB - A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode. Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis. Average recoveries of the eight target analytes are typically in the range of 91.8-122% with the relative standard deviations of 1.8-17.8%. The limits of quantification (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g. Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations.
UR - http://www.scopus.com/inward/record.url?scp=85042552678&partnerID=8YFLogxK
U2 - 10.1155/2018/9470254
DO - 10.1155/2018/9470254
M3 - Article
AN - SCOPUS:85042552678
SN - 2090-8865
VL - 2018
JO - Journal of Analytical Methods in Chemistry
JF - Journal of Analytical Methods in Chemistry
M1 - 9470254
ER -