Determinants of nicotine dependence in chronic obstructive pulmonary disease

Yun Su Sim, Jin Hwa Lee, Ki Uk Kim, Seung Won Ra, Hye Yun Park, Chang Hoon Lee, Deog Kyeom Kim, Kyeong Cheol Shin, Sang Haak Lee, Hun Gyu Hwang, Joong Hyun Ahn, Yong Bum Park, Yu Il Kim, Kwang Ha Yoo, Ina Jeong, Yeon Mok Oh, Sang Do Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. Methods: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016. Nicotine dependence was measured by using Fagerstrom test for nicotine dependence (FTND). Cognitive function was assessed by Korean version of Montreal Cognitive Assessment. Results: The median FTND score was 3, and 32 patients (60%) had moderate to high nicotine dependence. The median smoking amount was 44 pack-years, which was not related to nicotine dependence. Multiple logistic regression analysis revealed that high education status (odds ratio, 1.286; 95% confidence interval, 1.036-1.596; p=0.023), age <70 (odds ratio, 6.407; 95% confidence interval, 1.376-29.830; p=0.018), and mild to moderate airflow obstruction (odds ratio, 6.969; 95% confidence interval, 1.388-34.998; p=0.018) were related to moderate to high nicotine dependence. Conclusion: Nicotine dependence does not correlate with smoking amount, but with education level, age, and severity of airflow obstruction. Physicians should provide different strategies of smoking cessation intervention for current smokers with COPD according to their education levels, age, and severity of airflow obstruction.

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalTuberculosis and Respiratory Diseases
Issue number3
StatePublished - Jul 2017

Bibliographical note

Publisher Copyright:
Copyright © 2017 The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.


  • Chronic obstructive
  • Nicotine dependence
  • Pulmonary disease
  • Smoking cessation


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