Detection of protein conformational changes with a nanogap biosensor

J. T. Nevill; D. Di Carlo; P. Liu; K. H. Jeong; L. P. Lee

doi:10.1109/SENSOR.2005.1497410

Detection of protein conformational changes with a nanogap biosensor

J. T. Nevill
, D. Di Carlo
, P. Liu
, K. H. Jeong
, L. P. Lee

Department of Chemistry & Nanoscience

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

9 Scopus citations

Abstract

We demonstrate for the first time the detection of a conformational change in protein structure using a nanogap biosensor. Understanding the relationship between protein structure and function is paramount to unlocking life's processes on a molecular scale, and it is important to develop efficient measurement tools necessary to record these relationships. We have developed a unique nanoscale electrode-based biosensor that uses dielectric spectroscopy to interrogate samples inside a nanoscale gap, and we have shown that this biosensor is sensitive enough to record the conformational changes of a well known protein

Original language	English
Title of host publication	TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers
Pages	1668-1671
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2005.1497410
State	Published - 2005
Event	13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05 - Seoul, Korea, Republic of Duration: 5 Jun 2005 → 9 Jun 2005

Publication series

Name	Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Volume	2

Conference

Conference	13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Country/Territory	Korea, Republic of
City	Seoul
Period	5/06/05 → 9/06/05

Keywords

Biosensor
Nanogap
Protein conformation

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10.1109/SENSOR.2005.1497410

Cite this

Nevill, J. T., Di Carlo, D., Liu, P., Jeong, K. H., & Lee, L. P. (2005). Detection of protein conformational changes with a nanogap biosensor. In TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers (pp. 1668-1671). Article 3E4.93 (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05; Vol. 2). https://doi.org/10.1109/SENSOR.2005.1497410

Nevill, J. T. ; Di Carlo, D. ; Liu, P. et al. / Detection of protein conformational changes with a nanogap biosensor. TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers. 2005. pp. 1668-1671 (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05).

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title = "Detection of protein conformational changes with a nanogap biosensor",

abstract = "We demonstrate for the first time the detection of a conformational change in protein structure using a nanogap biosensor. Understanding the relationship between protein structure and function is paramount to unlocking life's processes on a molecular scale, and it is important to develop efficient measurement tools necessary to record these relationships. We have developed a unique nanoscale electrode-based biosensor that uses dielectric spectroscopy to interrogate samples inside a nanoscale gap, and we have shown that this biosensor is sensitive enough to record the conformational changes of a well known protein",

keywords = "Biosensor, Nanogap, Protein conformation",

author = "Nevill, \{J. T.\} and \{Di Carlo\}, D. and P. Liu and Jeong, \{K. H.\} and Lee, \{L. P.\}",

year = "2005",

doi = "10.1109/SENSOR.2005.1497410",

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isbn = "0780389948",

series = "Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05",

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booktitle = "TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers",

note = "13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05 ; Conference date: 05-06-2005 Through 09-06-2005",

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Nevill, JT, Di Carlo, D, Liu, P, Jeong, KH & Lee, LP 2005, Detection of protein conformational changes with a nanogap biosensor. in TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers., 3E4.93, Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05, vol. 2, pp. 1668-1671, 13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05, Seoul, Korea, Republic of, 5/06/05. https://doi.org/10.1109/SENSOR.2005.1497410

Detection of protein conformational changes with a nanogap biosensor. / Nevill, J. T.; Di Carlo, D.; Liu, P. et al.
TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers. 2005. p. 1668-1671 3E4.93 (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Jeong, K. H.

AU - Lee, L. P.

PY - 2005

Y1 - 2005

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AB - We demonstrate for the first time the detection of a conformational change in protein structure using a nanogap biosensor. Understanding the relationship between protein structure and function is paramount to unlocking life's processes on a molecular scale, and it is important to develop efficient measurement tools necessary to record these relationships. We have developed a unique nanoscale electrode-based biosensor that uses dielectric spectroscopy to interrogate samples inside a nanoscale gap, and we have shown that this biosensor is sensitive enough to record the conformational changes of a well known protein

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KW - Nanogap

KW - Protein conformation

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DO - 10.1109/SENSOR.2005.1497410

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T2 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05

Y2 - 5 June 2005 through 9 June 2005

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Nevill JT, Di Carlo D, Liu P, Jeong KH, Lee LP. Detection of protein conformational changes with a nanogap biosensor. In TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers. 2005. p. 1668-1671. 3E4.93. (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05). doi: 10.1109/SENSOR.2005.1497410

Detection of protein conformational changes with a nanogap biosensor

Abstract

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Keywords

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