Abstract
(Figure Presented) Turn off the light! A kinase assay system employs fluorescent peptides and a phosphate-selective fluorescence quencher probe, and can be placed on a microfluidic chip (see picture). The system can be used for real-time kinase monitoring, kinase inhibitor screening, and cancer diagnosis based on abnormal kinase activity observed in patients' samples.
Original language | English |
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Pages (from-to) | 4919-4923 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 29 |
DOIs | |
State | Published - 5 Jul 2010 |
Keywords
- Cancer
- Fluorescence
- Fluorescent probes
- Kinases
- Phosphorylation