Detection of kinase activity using versatile fluorescence quencher probes

Hyun Woo Rhee, Seung Hwan Lee, Ik Soo Shin, So Jung Choi, Hun Hee Park, Kyungja Han, Tai Hyun Park, Jong In Hong

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

(Figure Presented) Turn off the light! A kinase assay system employs fluorescent peptides and a phosphate-selective fluorescence quencher probe, and can be placed on a microfluidic chip (see picture). The system can be used for real-time kinase monitoring, kinase inhibitor screening, and cancer diagnosis based on abnormal kinase activity observed in patients' samples.

Original languageEnglish
Pages (from-to)4919-4923
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number29
DOIs
StatePublished - 5 Jul 2010

Keywords

  • Cancer
  • Fluorescence
  • Fluorescent probes
  • Kinases
  • Phosphorylation

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