Detection of epidermal growth factor receptor in the serum of gastric carcinoma patients

Jin Hyuk Choi, Jee Young Oh, Sung Ki Ryu, Seung Jung Kim, Na Young Lee, Young Sun Kim, Sun Young Yi, Kang Sup Shim, Woon Sup Han

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

BACKGROUND. Epidermal growth factor receptor (EGFR) is overexpressed in various malignancies including carcinoma of the breast, lung, esophagus, cervix, and stomach. In patients with gastric carcinoma, its overexpression may be associated with advanced stage and poor prognosis. METHODS. The levels of EGFR extracellular domain were determined in serum from 40 gastric carcinoma patients using enzyme-linked immunosorbent assay. Serum EGFR levels were measured in 5 Stage I, 2 Stage II, 6 Stage III, and 27 Stage IV patients, and 29 healthy controls. RESULTS. The mean serum level for EGFR in the gastric carcinoma patients was significantly elevated compared with that of healthy controls (681 ± 226 fmol/mL vs. 440 ± 46 fmol/mL; P < 0.0001). Thirty-one patients with gastric carcinoma (77.5%) showed elevated EGFR levels above a cutoff value of 532 fmol/mL (defined as 2 standard deviations above the mean of the controls). No significant association was noted between positivity of EGFR and gender, age, stage, and tumor differentiation. CONCLUSIONS. The authors believe that serum EGFR could be useful as a tumor marker of gastric carcinoma for diagnosis, prognosis, follow-up after surgery, and monitoring patient response to chemotherapy.

Original languageEnglish
Pages (from-to)1879-1883
Number of pages5
JournalCancer
Volume79
Issue number10
DOIs
StatePublished - 15 May 1997

Keywords

  • enzyme-linked immunosorbent assay
  • epidermal growth factor receptor
  • gastric carcinoma
  • serum
  • tumor marker

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