Designed Amyloid Fibers with Emergent Melanosomal Functions

Hyeyeon Park, Hyeri Jeon, Min Young Lee, Hyojae Jeon, Sunbum Kwon, Seungwoo Hong, Kyungtae Kang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Short peptides designed to self-associate into amyloid fibers with metal ion-binding ability have been used to catalyze various types of chemical reactions. This manuscript demonstrates that one of these short-peptide fibers coordinated with CuIIcan exhibit melanosomal functions. The coordinated CuIIand the amyloid structure itself are differentially functional in accelerating oxidative self-association of dopamine into melanin-like species and in regulating their material properties (e.g., water dispersion, morphology, and the density of unpaired electrons). The results have implications for the role of functional amyloids in melanin biosynthesis and for designing peptide-based supramolecular structures with various emergent functions.

Original languageEnglish
Pages (from-to)7077-7084
Number of pages8
Issue number22
StatePublished - 7 Jun 2022

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