Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Van Nghia Nguyen; Sang Jun Park; Sujie Qi; Jeongsun Ha; Seonye Heo; Yubin Yim; Gain Baek; Chang Su Lim; Dong Joon Lee; Hwan Myung Kim; Juyoung Yoon

doi:10.1039/d0cc04644b

Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Van Nghia Nguyen, Sang Jun Park, Sujie Qi, Jeongsun Ha, Seonye Heo, Yubin Yim, Gain Baek, Chang Su Lim, Dong Joon Lee, Hwan Myung Kim, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

Original language	English
Pages (from-to)	11489-11492
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	77
DOIs	https://doi.org/10.1039/d0cc04644b
State	Published - 4 Oct 2020

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2020.

Access to Document

10.1039/d0cc04644b

Cite this

@article{57fb3ab53b2a468a930dcb5d9873d40f,

title = "Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer",

abstract = "Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.",

author = "Nguyen, \{Van Nghia\} and Park, \{Sang Jun\} and Sujie Qi and Jeongsun Ha and Seonye Heo and Yubin Yim and Gain Baek and Lim, \{Chang Su\} and Lee, \{Dong Joon\} and Kim, \{Hwan Myung\} and Juyoung Yoon",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",

year = "2020",

month = oct,

day = "4",

doi = "10.1039/d0cc04644b",

language = "English",

volume = "56",

pages = "11489--11492",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "77",

}

TY - JOUR

T1 - Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

AU - Nguyen, Van Nghia

AU - Park, Sang Jun

AU - Qi, Sujie

AU - Ha, Jeongsun

AU - Heo, Seonye

AU - Yim, Yubin

AU - Baek, Gain

AU - Lim, Chang Su

AU - Lee, Dong Joon

AU - Kim, Hwan Myung

AU - Yoon, Juyoung

PY - 2020/10/4

Y1 - 2020/10/4

N2 - Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

AB - Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

UR - https://www.scopus.com/pages/publications/85091890742

U2 - 10.1039/d0cc04644b

DO - 10.1039/d0cc04644b

M3 - Article

C2 - 32857074

AN - SCOPUS:85091890742

SN - 1359-7345

VL - 56

SP - 11489

EP - 11492

JO - Chemical Communications

JF - Chemical Communications

IS - 77

ER -

Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this