Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Van Nghia Nguyen; Sang Jun Park; Sujie Qi; Jeongsun Ha; Seonye Heo; Yubin Yim; Gain Baek; Chang Su Lim; Dong Joon Lee; Hwan Myung Kim; Juyoung Yoon

doi:10.1039/d0cc04644b

Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Van Nghia Nguyen
, Sang Jun Park
, Sujie Qi
, Jeongsun Ha
, Seonye Heo
, Yubin Yim
, Gain Baek
, Chang Su Lim
, Dong Joon Lee
, Hwan Myung Kim
, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

Original language	English
Pages (from-to)	11489-11492
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	77
DOIs	https://doi.org/10.1039/d0cc04644b
State	Published - 4 Oct 2020

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© The Royal Society of Chemistry 2020.

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title = "Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer",

abstract = "Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.",

author = "Nguyen, \{Van Nghia\} and Park, \{Sang Jun\} and Sujie Qi and Jeongsun Ha and Seonye Heo and Yubin Yim and Gain Baek and Lim, \{Chang Su\} and Lee, \{Dong Joon\} and Kim, \{Hwan Myung\} and Juyoung Yoon",

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doi = "10.1039/d0cc04644b",

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TY - JOUR

T1 - Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

AU - Nguyen, Van Nghia

AU - Park, Sang Jun

AU - Qi, Sujie

AU - Ha, Jeongsun

AU - Heo, Seonye

AU - Yim, Yubin

AU - Baek, Gain

AU - Lim, Chang Su

AU - Lee, Dong Joon

AU - Kim, Hwan Myung

AU - Yoon, Juyoung

PY - 2020/10/4

Y1 - 2020/10/4

N2 - Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

AB - Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

UR - https://www.scopus.com/pages/publications/85091890742

U2 - 10.1039/d0cc04644b

DO - 10.1039/d0cc04644b

M3 - Article

C2 - 32857074

AN - SCOPUS:85091890742

SN - 1359-7345

VL - 56

SP - 11489

EP - 11492

JO - Chemical Communications

JF - Chemical Communications

IS - 77

ER -

Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Abstract

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