Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Van Nghia Nguyen; Sang Jun Park; Sujie Qi; Jeongsun Ha; Seonye Heo; Yubin Yim; Gain Baek; Chang Su Lim; Dong Joon Lee; Hwan Myung Kim; Juyoung Yoon

doi:10.1039/d0cc04644b

Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Van Nghia Nguyen, Sang Jun Park, Sujie Qi, Jeongsun Ha, Seonye Heo, Yubin Yim, Gain Baek, Chang Su Lim, Dong Joon Lee, Hwan Myung Kim, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

Original language	English
Pages (from-to)	11489-11492
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	77
DOIs	https://doi.org/10.1039/d0cc04644b
State	Published - 4 Oct 2020

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© The Royal Society of Chemistry 2020.

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title = "Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer",

abstract = "Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.",

author = "Nguyen, {Van Nghia} and Park, {Sang Jun} and Sujie Qi and Jeongsun Ha and Seonye Heo and Yubin Yim and Gain Baek and Lim, {Chang Su} and Lee, {Dong Joon} and Kim, {Hwan Myung} and Juyoung Yoon",

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doi = "10.1039/d0cc04644b",

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T1 - Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

AU - Nguyen, Van Nghia

AU - Park, Sang Jun

AU - Qi, Sujie

AU - Ha, Jeongsun

AU - Heo, Seonye

AU - Yim, Yubin

AU - Baek, Gain

AU - Lim, Chang Su

AU - Lee, Dong Joon

AU - Kim, Hwan Myung

AU - Yoon, Juyoung

PY - 2020/10/4

Y1 - 2020/10/4

N2 - Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

AB - Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

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U2 - 10.1039/d0cc04644b

DO - 10.1039/d0cc04644b

M3 - Article

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AN - SCOPUS:85091890742

SN - 1359-7345

VL - 56

SP - 11489

EP - 11492

JO - Chemical Communications

JF - Chemical Communications

IS - 77

ER -

Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Abstract

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