Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Van Nghia Nguyen, Sang Jun Park, Sujie Qi, Jeongsun Ha, Seonye Heo, Yubin Yim, Gain Baek, Chang Su Lim, Dong Joon Lee, Hwan Myung Kim, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular,NIS-MeandCRNSdisplay outstanding phototoxicity toward HeLa cells under two-photon excitation (800 nm) with negligible dark toxicity.

Original languageEnglish
Pages (from-to)11489-11492
Number of pages4
JournalChemical Communications
Volume56
Issue number77
DOIs
StatePublished - 4 Oct 2020

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