Abstract
6-Fluoropurine acyclonucleosides 6 and 7 have been prepared as potential prodrugs of acyclovir and ganciclovir. It has been found that compounds 6 and 7 are 11.6 and 7.6 times more efficiently metabolized to acyclovir and ganciclovir by adenosine deaminase than the corresponding 6-aminopurine acyclonucleosides 4 and 12, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 1309-1312 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 4 |
| Issue number | 11 |
| DOIs | |
| State | Published - 9 Jun 1994 |