Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Sang Sup Jew; Eun Kyung Kim; Sun Mi Je; Long Xuan Zhao; Hyung Ook Kim; Hyeung Geun Park; Kwang Ho Ko; Won Ki Kim; Hwa Jung Kim; Jae Hoon Cheong; Eung Seok Lee

doi:10.3987/COM-98-8235

Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Sang Sup Jew
, Eun Kyung Kim
, Sun Mi Je
, Long Xuan Zhao
, Hyung Ook Kim
, Hyeung Geun Park
, Kwang Ho Ko
, Won Ki Kim
, Hwa Jung Kim
, Jae Hoon Cheong
, Eung Seok Lee

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

Original language	English
Pages (from-to)	1087-1103
Number of pages	17
Journal	Heterocycles
Volume	52
Issue number	3
DOIs	https://doi.org/10.3987/COM-98-8235
State	Published - 1 Mar 2000

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title = "Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities",

abstract = "A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).",

author = "Jew, \{Sang Sup\} and Kim, \{Eun Kyung\} and Je, \{Sun Mi\} and Zhao, \{Long Xuan\} and Kim, \{Hyung Ook\} and Park, \{Hyeung Geun\} and Ko, \{Kwang Ho\} and Kim, \{Won Ki\} and Kim, \{Hwa Jung\} and Cheong, \{Jae Hoon\} and Lee, \{Eung Seok\}",

year = "2000",

month = mar,

day = "1",

doi = "10.3987/COM-98-8235",

language = "English",

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journal = "Heterocycles",

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T1 - Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

AU - Jew, Sang Sup

AU - Kim, Eun Kyung

AU - Je, Sun Mi

AU - Zhao, Long Xuan

AU - Kim, Hyung Ook

AU - Park, Hyeung Geun

AU - Ko, Kwang Ho

AU - Kim, Won Ki

AU - Kim, Hwa Jung

AU - Cheong, Jae Hoon

AU - Lee, Eung Seok

PY - 2000/3/1

Y1 - 2000/3/1

N2 - A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

AB - A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).

UR - https://www.scopus.com/pages/publications/0034162704

U2 - 10.3987/COM-98-8235

DO - 10.3987/COM-98-8235

M3 - Article

AN - SCOPUS:0034162704

SN - 0385-5414

VL - 52

SP - 1087

EP - 1103

JO - Heterocycles

JF - Heterocycles

IS - 3

ER -

Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Abstract

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