Design and engineering of whole-cell biocatalytic cascades for the valorization of fatty acids

Ji Won Song, Joo Hyun Seo, Doek Kun Oh, Uwe T. Bornscheuer, Jin Byung Park

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

One of the key factors to construct a productive whole-cell biocatalytic cascade may include the design of the biotransformation pathways, discovery and engineering of the cascade enzymes, and functional and balanced expression of the cascade enzymes in microbial cells as well as systematic engineering of the whole-cell biocatalytic cascades. Such issues are covered in this review exemplified for the biotransformation of renewable fatty acids into industrially relevant oleochemicals (e.g., medium-chain fatty acids such as n-nonanoic acid, 9-hydroxynonanoic acid, 9-aminononanoic acid, and 1,9-nonanedioic acid) as model systems.

Original languageEnglish
Pages (from-to)46-64
Number of pages19
JournalCatalysis Science and Technology
Volume10
Issue number1
DOIs
StatePublished - 2020

Bibliographical note

Funding Information:
This study was supported by the C1 Gas Refinery Research Center (NRF Grant Number: 2018M3D3A1A01055735) of the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT. J.-W. Song was partially supported by RP-Grant 2019 of Ewha Womans University. J.-H. Seo was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2017R1D1A1B03033525).

Publisher Copyright:
This journal is © The Royal Society of Chemistry.

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