Design and applications of fluorescent detectors for peroxynitrite

Shan Wang, Liyan Chen, Paramesh Jangili, Amit Sharma, Wei Li, Ji Ting Hou, Caiqin Qin, Juyoung Yoon, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

Peroxynitrite (ONOO) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO and their biological applications in diverse living systems.

Original languageEnglish
Pages (from-to)36-54
Number of pages19
JournalCoordination Chemistry Reviews
Volume374
DOIs
StatePublished - 1 Nov 2018

Keywords

  • Boronic acids or boronates
  • Fluorescence probes
  • In vivo imaging
  • Intracellular imaging
  • N-dearylation
  • Peroxynitrite
  • Reactive oxygen species (ROS)

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