Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617

Se Eun Lee, Min Ju Kim, Prima F. Hillman, Dong Chan Oh, William Fenical, Sang Jip Nam, Kyung Min Lim

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10 Scopus citations


The tricyclic quinazoline alkaloid deoxyvasicinone (DOV, 1) was isolated from a marinederived Streptomyces sp. CNQ-617, and its anti-melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the melanin content of B16F10 and MNT-1 cells that have been stimulated by α-melanocyte-stimulating hormone (α-MSH). In addition, microscopic images of the cells showed that deoxyvasicinone attenuated melanocyte activation. Although, deoxyvasicinone did not directly inhibit tyrosinase (TYR) enzymatic activity, real-time PCR showed that it inhibited the mRNA expression of TYR, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2). In the artificial 3D pigmented skin model Melanoderm™, deoxyvasicinone brightened the skin significantly, as confirmed by histological examination. In conclusion, this study demonstrated that the marine microbial natural product deoxyvascinone has an anti-melanogenic effect through downregulation of melanogenic enzymes.

Original languageEnglish
Article number155
JournalMarine Drugs
Issue number2
StatePublished - Feb 2022

Bibliographical note

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • Anti-melanogenic effect
  • Deoxyvasicinone
  • Marine natural products
  • Streptomyces sp


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