Dendrimeric siRNA for efficient gene silencing

Cheol Am Hong, Ahmed A. Eltoukhy, Hyukjin Lee, Robert Langer, Daniel G. Anderson, Yoon Sung Nam

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(β-amino ester), PBAE) to generate stable nanostructures about 160 nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.

Original languageEnglish
Pages (from-to)6740-6744
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number23
DOIs
StatePublished - 1 Jun 2015

Keywords

  • dendrimeric nanostructures
  • gene silencing
  • poly(β-amino ester)
  • polymeric condensation
  • siRNA

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