Dendrimeric siRNA for efficient gene silencing

Cheol Am Hong, Ahmed A. Eltoukhy, Hyukjin Lee, Robert Langer, Daniel G. Anderson, Yoon Sung Nam

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(β-amino ester), PBAE) to generate stable nanostructures about 160 nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.

Original languageEnglish
Pages (from-to)6740-6744
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number23
StatePublished - 1 Jun 2015

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


  • dendrimeric nanostructures
  • gene silencing
  • poly(β-amino ester)
  • polymeric condensation
  • siRNA


Dive into the research topics of 'Dendrimeric siRNA for efficient gene silencing'. Together they form a unique fingerprint.

Cite this