Dendrimeric siRNA for efficient gene silencing

Cheol Am Hong; Ahmed A. Eltoukhy; Hyukjin Lee; Robert Langer; Daniel G. Anderson; Yoon Sung Nam

doi:10.1002/anie.201412493

Dendrimeric siRNA for efficient gene silencing

Cheol Am Hong, Ahmed A. Eltoukhy, Hyukjin Lee, Robert Langer, Daniel G. Anderson, Yoon Sung Nam

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(β-amino ester), PBAE) to generate stable nanostructures about 160 nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.

Original language	English
Pages (from-to)	6740-6744
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	23
DOIs	https://doi.org/10.1002/anie.201412493
State	Published - 1 Jun 2015

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

dendrimeric nanostructures
gene silencing
poly(β-amino ester)
polymeric condensation
siRNA

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10.1002/anie.201412493

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AU - Eltoukhy, Ahmed A.

AU - Lee, Hyukjin

AU - Langer, Robert

AU - Anderson, Daniel G.

AU - Nam, Yoon Sung

PY - 2015/6/1

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KW - dendrimeric nanostructures

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KW - poly(β-amino ester)

KW - polymeric condensation

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Dendrimeric siRNA for efficient gene silencing

Abstract

Bibliographical note

Keywords

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