Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory

Hyopil Kim; Somi Kim; Ja Eun Choi; Dae Hee Han; Soo Min Koh; Hyun Seok Kim; Bong Kiun Kaang

doi:10.1007/s11064-017-2417-3

Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory

Hyopil Kim, Somi Kim, Ja Eun Choi, Dae Hee Han, Soo Min Koh, Hyun Seok Kim, Bong Kiun Kaang

Department of Life Science

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The sirtuin family of proteins consists of nicotinamide adenine dinucleotide-dependent deacetylases that are involved in the response to calorie restriction and various physiological phenomena, such as aging and cognition. One of these proteins, sirtuin 3 (SIRT3), is localized in the mitochondria and protects the cell against oxidative or metabolic stress. Sirtuin protein deficiencies have been shown to accelerate neurodegeneration in neurotoxic conditions. The mechanisms underlying the involvement of SIRT3 in cognition remain unclear. Interestingly, SIRT1, another member of the sirtuin family, has been reported to modulate synaptic plasticity and memory formation. To learn more about these proteins, we examined the behavior and cognitive functions of Sirt3-knockout mice. The mice exhibited poor remote memory. Consistent with this, long-term potentiation was impaired in the Sirt3-knockout mice, and they exhibited decreased neuronal number in the anterior cingulate cortex, which seemed to contribute to their memory deficiencies.

Original language	English
Pages (from-to)	676-682
Number of pages	7
Journal	Neurochemical Research
Volume	44
Issue number	3
DOIs	https://doi.org/10.1007/s11064-017-2417-3
State	Published - 1 Mar 2019

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the National Honour Scientist Program of Korea (to B.K.K., NRF2012R1A3A1050385) and National Research Foundation of Korea (NRF) grants (to H.S.K., NRF2012R1A5A1048236 and NRF2012M3A9C5048708). We thank the members of the Kaang lab for their technical assistance.

Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.

Keywords

Neurodegeneration
Remote memory
Sirtuin
Synaptic plasticity

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10.1007/s11064-017-2417-3

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title = "Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory",

abstract = "The sirtuin family of proteins consists of nicotinamide adenine dinucleotide-dependent deacetylases that are involved in the response to calorie restriction and various physiological phenomena, such as aging and cognition. One of these proteins, sirtuin 3 (SIRT3), is localized in the mitochondria and protects the cell against oxidative or metabolic stress. Sirtuin protein deficiencies have been shown to accelerate neurodegeneration in neurotoxic conditions. The mechanisms underlying the involvement of SIRT3 in cognition remain unclear. Interestingly, SIRT1, another member of the sirtuin family, has been reported to modulate synaptic plasticity and memory formation. To learn more about these proteins, we examined the behavior and cognitive functions of Sirt3-knockout mice. The mice exhibited poor remote memory. Consistent with this, long-term potentiation was impaired in the Sirt3-knockout mice, and they exhibited decreased neuronal number in the anterior cingulate cortex, which seemed to contribute to their memory deficiencies.",

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AU - Koh, Soo Min

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AU - Kaang, Bong Kiun

N1 - Funding Information: Acknowledgements This work was supported by the National Honour Scientist Program of Korea (to B.K.K., NRF2012R1A3A1050385) and National Research Foundation of Korea (NRF) grants (to H.S.K., NRF2012R1A5A1048236 and NRF2012M3A9C5048708). We thank the members of the Kaang lab for their technical assistance. Publisher Copyright: © 2017, Springer Science+Business Media, LLC.

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N2 - The sirtuin family of proteins consists of nicotinamide adenine dinucleotide-dependent deacetylases that are involved in the response to calorie restriction and various physiological phenomena, such as aging and cognition. One of these proteins, sirtuin 3 (SIRT3), is localized in the mitochondria and protects the cell against oxidative or metabolic stress. Sirtuin protein deficiencies have been shown to accelerate neurodegeneration in neurotoxic conditions. The mechanisms underlying the involvement of SIRT3 in cognition remain unclear. Interestingly, SIRT1, another member of the sirtuin family, has been reported to modulate synaptic plasticity and memory formation. To learn more about these proteins, we examined the behavior and cognitive functions of Sirt3-knockout mice. The mice exhibited poor remote memory. Consistent with this, long-term potentiation was impaired in the Sirt3-knockout mice, and they exhibited decreased neuronal number in the anterior cingulate cortex, which seemed to contribute to their memory deficiencies.

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Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory

Abstract

Bibliographical note

Keywords

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