Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: A proton magnetic resonance spectroscopy (1H-MRS) study

Byung Joo Ham; Younghoon Sung; Namkug Kim; Seog Ju Kim; Jieun E. Kim; Dajung J. Kim; Jeeyoung Y. Lee; Jihyun H. Kim; Sujung J. Yoon; In Kyoon Lyoo

doi:10.1016/j.pnpbp.2006.10.011

Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: A proton magnetic resonance spectroscopy (¹H-MRS) study

Byung Joo Ham, Younghoon Sung, Namkug Kim, Seog Ju Kim, Jieun E. Kim, Dajung J. Kim, Jeeyoung Y. Lee, Jihyun H. Kim, Sujung J. Yoon, In Kyoon Lyoo

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The purpose of this study was to investigate the brain gamma-aminobutyric acid (GABA) concentration and its relationship with clinical variables in patients with panic disorder (PD). Single voxel proton magnetic resonance spectroscopy (¹H-MRS) scan was performed on 22 medicated subjects with PD and 25 age and sex-matched healthy comparison subjects. GABA and other metabolite levels were measured in the anterior cingulate cortex (ACC) and basal ganglia. GABA levels were significantly lower in the ACC and basal ganglia of PD patients relative to comparison subjects. Lactate and choline concentrations in the ACC in PD patients were also higher than in the comparison subjects. Our data suggested in part that alterations of the GABA function and the energy metabolism in ACC and basal ganglia may play an important role in the pathophysiology of panic disorder.

Original language	English
Pages (from-to)	403-411
Number of pages	9
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.pnpbp.2006.10.011
State	Published - 30 Mar 2007

Bibliographical note

Funding Information:
This research was supported by grants from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, the Republic of Korea (60%)(M103KV010022-06K2201-02210; I.K.L.), the Korea Health 21 R and D Project, Ministry of Health and Welfare, Republic of Korea (A06-0434-A21018-06N1-00010A; I.K.L.), SNUH (21-2004-008-0) and 2006 NARSAD Independent Investigator Award (Great Neck, NY, USA; I.K.L.).

Keywords

Gamma-aminobutyric acid
Magnetic resonance spectroscopy
Panic disorder

Access to Document

10.1016/j.pnpbp.2006.10.011

Cite this

Ham, B. J., Sung, Y., Kim, N., Kim, S. J., Kim, J. E., Kim, D. J., Lee, J. Y., Kim, J. H., Yoon, S. J., & Lyoo, I. K. (2007). Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: A proton magnetic resonance spectroscopy (¹H-MRS) study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(2), 403-411. https://doi.org/10.1016/j.pnpbp.2006.10.011

@article{53ec605ec4854ba28ecefbfee8168109,

title = "Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: A proton magnetic resonance spectroscopy (1H-MRS) study",

abstract = "The purpose of this study was to investigate the brain gamma-aminobutyric acid (GABA) concentration and its relationship with clinical variables in patients with panic disorder (PD). Single voxel proton magnetic resonance spectroscopy (1H-MRS) scan was performed on 22 medicated subjects with PD and 25 age and sex-matched healthy comparison subjects. GABA and other metabolite levels were measured in the anterior cingulate cortex (ACC) and basal ganglia. GABA levels were significantly lower in the ACC and basal ganglia of PD patients relative to comparison subjects. Lactate and choline concentrations in the ACC in PD patients were also higher than in the comparison subjects. Our data suggested in part that alterations of the GABA function and the energy metabolism in ACC and basal ganglia may play an important role in the pathophysiology of panic disorder.",

keywords = "Gamma-aminobutyric acid, Magnetic resonance spectroscopy, Panic disorder",

author = "Ham, {Byung Joo} and Younghoon Sung and Namkug Kim and Kim, {Seog Ju} and Kim, {Jieun E.} and Kim, {Dajung J.} and Lee, {Jeeyoung Y.} and Kim, {Jihyun H.} and Yoon, {Sujung J.} and Lyoo, {In Kyoon}",

note = "Funding Information: This research was supported by grants from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, the Republic of Korea (60%)(M103KV010022-06K2201-02210; I.K.L.), the Korea Health 21 R and D Project, Ministry of Health and Welfare, Republic of Korea (A06-0434-A21018-06N1-00010A; I.K.L.), SNUH (21-2004-008-0) and 2006 NARSAD Independent Investigator Award (Great Neck, NY, USA; I.K.L.).",

year = "2007",

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doi = "10.1016/j.pnpbp.2006.10.011",

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Ham, BJ, Sung, Y, Kim, N, Kim, SJ, Kim, JE, Kim, DJ, Lee, JY, Kim, JH, Yoon, SJ & Lyoo, IK 2007, 'Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: A proton magnetic resonance spectroscopy (¹H-MRS) study', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 31, no. 2, pp. 403-411. https://doi.org/10.1016/j.pnpbp.2006.10.011

Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: A proton magnetic resonance spectroscopy (¹H-MRS) study. / Ham, Byung Joo; Sung, Younghoon; Kim, Namkug et al.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 31, No. 2, 30.03.2007, p. 403-411.

Research output: Contribution to journal › Article › peer-review

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AU - Sung, Younghoon

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AU - Kim, Seog Ju

AU - Kim, Jieun E.

AU - Kim, Dajung J.

AU - Lee, Jeeyoung Y.

AU - Kim, Jihyun H.

AU - Yoon, Sujung J.

AU - Lyoo, In Kyoon

N1 - Funding Information: This research was supported by grants from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, the Republic of Korea (60%)(M103KV010022-06K2201-02210; I.K.L.), the Korea Health 21 R and D Project, Ministry of Health and Welfare, Republic of Korea (A06-0434-A21018-06N1-00010A; I.K.L.), SNUH (21-2004-008-0) and 2006 NARSAD Independent Investigator Award (Great Neck, NY, USA; I.K.L.).

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