Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Jaeuk Hwang; In Kyoon Lyoo; Seog Ju Kim; Young Hoon Sung; Soojeong Bae; Sung Nam Cho; Ho Young Lee; Dong Soo Lee; Perry F. Renshaw

doi:10.1016/j.drugalcdep.2005.09.011

Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Jaeuk Hwang
, In Kyoon Lyoo
, Seog Ju Kim
, Young Hoon Sung
, Soojeong Bae
, Sung Nam Cho
, Ho Young Lee
, Dong Soo Lee
, Perry F. Renshaw

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (^99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Drug and Alcohol Dependence
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/j.drugalcdep.2005.09.011
State	Published - 28 Apr 2006

Bibliographical note

Funding Information:
This work was supported by grants from the Health Technology Infrastructure Development Project of Korea Health Industry Development Institute (03-PJ1-PG3-21300-0069).

Keywords

Abstinence
Anterior cingulate
Cerebral blood flow
Methamphetamine
Single photon emission computed tomography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.drugalcdep.2005.09.011

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@article{2b6c9d4e3cad4256affc3c771462aeb3,

title = "Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users",

abstract = "Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.",

keywords = "Abstinence, Anterior cingulate, Cerebral blood flow, Methamphetamine, Single photon emission computed tomography",

author = "Jaeuk Hwang and Lyoo, \{In Kyoon\} and Kim, \{Seog Ju\} and Sung, \{Young Hoon\} and Soojeong Bae and Cho, \{Sung Nam\} and Lee, \{Ho Young\} and Lee, \{Dong Soo\} and Renshaw, \{Perry F.\}",

note = "Funding Information: This work was supported by grants from the Health Technology Infrastructure Development Project of Korea Health Industry Development Institute (03-PJ1-PG3-21300-0069). ",

year = "2006",

month = apr,

day = "28",

doi = "10.1016/j.drugalcdep.2005.09.011",

language = "English",

volume = "82",

pages = "177--181",

journal = "Drug and Alcohol Dependence",

issn = "0376-8716",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

AU - Hwang, Jaeuk

AU - Lyoo, In Kyoon

AU - Kim, Seog Ju

AU - Sung, Young Hoon

AU - Bae, Soojeong

AU - Cho, Sung Nam

AU - Lee, Ho Young

AU - Lee, Dong Soo

AU - Renshaw, Perry F.

N1 - Funding Information: This work was supported by grants from the Health Technology Infrastructure Development Project of Korea Health Industry Development Institute (03-PJ1-PG3-21300-0069).

PY - 2006/4/28

Y1 - 2006/4/28

N2 - Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.

AB - Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.

KW - Abstinence

KW - Anterior cingulate

KW - Cerebral blood flow

KW - Methamphetamine

KW - Single photon emission computed tomography

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U2 - 10.1016/j.drugalcdep.2005.09.011

DO - 10.1016/j.drugalcdep.2005.09.011

M3 - Article

C2 - 16253441

AN - SCOPUS:33645236326

SN - 0376-8716

VL - 82

SP - 177

EP - 181

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

IS - 2

ER -

Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Abstract

Bibliographical note

Keywords

UN SDGs

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