Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Jaeuk Hwang, In Kyoon Lyoo, Seog Ju Kim, Young Hoon Sung, Soojeong Bae, Sung Nam Cho, Ho Young Lee, Dong Soo Lee, Perry F. Renshaw

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalDrug and Alcohol Dependence
Volume82
Issue number2
DOIs
StatePublished - 28 Apr 2006

Keywords

  • Abstinence
  • Anterior cingulate
  • Cerebral blood flow
  • Methamphetamine
  • Single photon emission computed tomography

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