Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Jaeuk Hwang; In Kyoon Lyoo; Seog Ju Kim; Young Hoon Sung; Soojeong Bae; Sung Nam Cho; Ho Young Lee; Dong Soo Lee; Perry F. Renshaw

doi:10.1016/j.drugalcdep.2005.09.011

Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Jaeuk Hwang, In Kyoon Lyoo, Seog Ju Kim, Young Hoon Sung, Soojeong Bae, Sung Nam Cho, Ho Young Lee, Dong Soo Lee, Perry F. Renshaw

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (^99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Drug and Alcohol Dependence
Volume	82
Issue number	2
DOIs	https://doi.org/10.1016/j.drugalcdep.2005.09.011
State	Published - 28 Apr 2006

Bibliographical note

Funding Information:
This work was supported by grants from the Health Technology Infrastructure Development Project of Korea Health Industry Development Institute (03-PJ1-PG3-21300-0069).

Keywords

Abstinence
Anterior cingulate
Cerebral blood flow
Methamphetamine
Single photon emission computed tomography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.drugalcdep.2005.09.011

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title = "Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users",

abstract = "Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.",

keywords = "Abstinence, Anterior cingulate, Cerebral blood flow, Methamphetamine, Single photon emission computed tomography",

author = "Jaeuk Hwang and Lyoo, {In Kyoon} and Kim, {Seog Ju} and Sung, {Young Hoon} and Soojeong Bae and Cho, {Sung Nam} and Lee, {Ho Young} and Lee, {Dong Soo} and Renshaw, {Perry F.}",

note = "Funding Information: This work was supported by grants from the Health Technology Infrastructure Development Project of Korea Health Industry Development Institute (03-PJ1-PG3-21300-0069). ",

year = "2006",

month = apr,

day = "28",

doi = "10.1016/j.drugalcdep.2005.09.011",

language = "English",

volume = "82",

pages = "177--181",

journal = "Drug and Alcohol Dependence",

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TY - JOUR

T1 - Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

AU - Hwang, Jaeuk

AU - Lyoo, In Kyoon

AU - Kim, Seog Ju

AU - Sung, Young Hoon

AU - Bae, Soojeong

AU - Cho, Sung Nam

AU - Lee, Ho Young

AU - Lee, Dong Soo

AU - Renshaw, Perry F.

N1 - Funding Information: This work was supported by grants from the Health Technology Infrastructure Development Project of Korea Health Industry Development Institute (03-PJ1-PG3-21300-0069).

PY - 2006/4/28

Y1 - 2006/4/28

N2 - Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.

AB - Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl- propylene amine oxime (99mTc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (≥6 months) abstinence. Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.

KW - Abstinence

KW - Anterior cingulate

KW - Cerebral blood flow

KW - Methamphetamine

KW - Single photon emission computed tomography

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Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users

Abstract

Bibliographical note

Keywords

UN SDGs

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