Decreased cerebral blood flow of thalamus in PTSD patients as a strategy to reduce re-experience symptoms

S. J. Kim; I. K. Lyoo; Y. S. Lee; J. Kim; M. E. Sim; S. J. Bae; H. J. Kim; J. Y. Lee; D. U. Jeong

doi:10.1111/j.1600-0447.2006.00952.x

Decreased cerebral blood flow of thalamus in PTSD patients as a strategy to reduce re-experience symptoms

S. J. Kim, I. K. Lyoo, Y. S. Lee, J. Kim, M. E. Sim, S. J. Bae, H. J. Kim, J. Y. Lee, D. U. Jeong

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Objective: To investigate alterations of regional cerebral blood flow (rCBF) in subjects with post-traumatic stress disorder (PTSD). Method: Using [99Tcm]-hexamethyl propylenamino oxime single photon emission computed tomography, the rCBF under resting condition was compared between 19 survivors of the Taegu subway fire with PTSD and 19 comparison subjects. Results: PTSD patients showed a decreased rCBF in the right thalamus and an increased rCBF in the right superior parietal lobe relative to comparison subjects (corrected P < 0.05). The rCBF in the right thalamus positively correlated with the severity of current re-experience symptoms in PTSD subjects. Conclusion: Our finding of the thalamic rCBF decrease in PTSD patients may be a strategy to reduce re-experience symptom, by evading the process of external and internal information which can evoke traumatic memory. In addition, the parietal rCBF increase in our PTSD patients might be related to altered information processing in PTSD.

Original language	English
Pages (from-to)	145-153
Number of pages	9
Journal	Acta Psychiatrica Scandinavica
Volume	116
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0447.2006.00952.x
State	Published - Aug 2007

Keywords

Parietal lobe
Post-traumatic stress disorder
Single photon emission computed tomography
Thalamus

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0447.2006.00952.x

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abstract = "Objective: To investigate alterations of regional cerebral blood flow (rCBF) in subjects with post-traumatic stress disorder (PTSD). Method: Using [99Tcm]-hexamethyl propylenamino oxime single photon emission computed tomography, the rCBF under resting condition was compared between 19 survivors of the Taegu subway fire with PTSD and 19 comparison subjects. Results: PTSD patients showed a decreased rCBF in the right thalamus and an increased rCBF in the right superior parietal lobe relative to comparison subjects (corrected P < 0.05). The rCBF in the right thalamus positively correlated with the severity of current re-experience symptoms in PTSD subjects. Conclusion: Our finding of the thalamic rCBF decrease in PTSD patients may be a strategy to reduce re-experience symptom, by evading the process of external and internal information which can evoke traumatic memory. In addition, the parietal rCBF increase in our PTSD patients might be related to altered information processing in PTSD.",

keywords = "Parietal lobe, Post-traumatic stress disorder, Single photon emission computed tomography, Thalamus",

author = "Kim, {S. J.} and Lyoo, {I. K.} and Lee, {Y. S.} and J. Kim and Sim, {M. E.} and Bae, {S. J.} and Kim, {H. J.} and Lee, {J. Y.} and Jeong, {D. U.}",

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AU - Lee, Y. S.

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AU - Sim, M. E.

AU - Bae, S. J.

AU - Kim, H. J.

AU - Lee, J. Y.

AU - Jeong, D. U.

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N2 - Objective: To investigate alterations of regional cerebral blood flow (rCBF) in subjects with post-traumatic stress disorder (PTSD). Method: Using [99Tcm]-hexamethyl propylenamino oxime single photon emission computed tomography, the rCBF under resting condition was compared between 19 survivors of the Taegu subway fire with PTSD and 19 comparison subjects. Results: PTSD patients showed a decreased rCBF in the right thalamus and an increased rCBF in the right superior parietal lobe relative to comparison subjects (corrected P < 0.05). The rCBF in the right thalamus positively correlated with the severity of current re-experience symptoms in PTSD subjects. Conclusion: Our finding of the thalamic rCBF decrease in PTSD patients may be a strategy to reduce re-experience symptom, by evading the process of external and internal information which can evoke traumatic memory. In addition, the parietal rCBF increase in our PTSD patients might be related to altered information processing in PTSD.

AB - Objective: To investigate alterations of regional cerebral blood flow (rCBF) in subjects with post-traumatic stress disorder (PTSD). Method: Using [99Tcm]-hexamethyl propylenamino oxime single photon emission computed tomography, the rCBF under resting condition was compared between 19 survivors of the Taegu subway fire with PTSD and 19 comparison subjects. Results: PTSD patients showed a decreased rCBF in the right thalamus and an increased rCBF in the right superior parietal lobe relative to comparison subjects (corrected P < 0.05). The rCBF in the right thalamus positively correlated with the severity of current re-experience symptoms in PTSD subjects. Conclusion: Our finding of the thalamic rCBF decrease in PTSD patients may be a strategy to reduce re-experience symptom, by evading the process of external and internal information which can evoke traumatic memory. In addition, the parietal rCBF increase in our PTSD patients might be related to altered information processing in PTSD.

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Decreased cerebral blood flow of thalamus in PTSD patients as a strategy to reduce re-experience symptoms

Abstract

Keywords

UN SDGs

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