TY - JOUR
T1 - Deaths from tuberculosis
T2 - differences between tuberculosis-related and non-tuberculosis-related deaths
AU - Jeong, Yun Jeong
AU - Park, Jae Seuk
AU - Kim, Hyung Woo
AU - Min, Jinsoo
AU - Ko, Yousang
AU - Oh, Jee Youn
AU - Lee, Eun Hye
AU - Yang, Bumhee
AU - Lee, Min Ki
AU - Kim, Yun Seong
AU - Chang, Jung Hyun
AU - Jegal, Yangjin
AU - Lee, Sung Soon
AU - Kim, Ju Sang
AU - Koo, Hyeon Kyoung
N1 - Publisher Copyright:
Copyright © 2023 Jeong, Park, Kim, Min, Ko, Oh, Lee, Yang, Lee, Kim, Chang, Jegal, Lee, Kim and Koo.
PY - 2023
Y1 - 2023
N2 - Objective: Tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide. The first step in developing strategies to reduce TB mortality is to identify the direct causes of death in patients with TB and the risk factors for each cause. Methods: Data on patients with TB systemically collected from the National Surveillance System of South Korea from January 2019 to December 2020 were included in this study. We analyzed the clinical characteristics associated with TB and non-TB-related deaths, including TB-related symptoms, comorbidities, and radiographic and microbiological findings. Results: Of the total of 12,340 patients with TB, 61% were males with a mean age of 61.3 years. During the follow-up period, the overall mortality rate was 10.6%, with TB-related deaths accounting for 21.3% of all TB deaths. The median survival time in the TB-related death group was 22 days. TB-related death was associated with older age, lower body mass index (BMI), dyspnea, fever, general weakness, bilateral radiographic patterns, and acid-fast bacilli (AFB)-positive smears. Non-TB-related deaths were associated with older age, male sex, lower BMI, comorbidities of heart, liver, kidney, and central nervous system (CNS) diseases, CNS TB involvement, the presence of dyspnea, general weakness, and bilateral radiographic patterns. Conclusion: Patients with high-risk TB must be identified through cause-specific mortality analysis, and the mortality rate must be reduced through intensive monitoring of patients with a high TB burden and comorbidities.
AB - Objective: Tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide. The first step in developing strategies to reduce TB mortality is to identify the direct causes of death in patients with TB and the risk factors for each cause. Methods: Data on patients with TB systemically collected from the National Surveillance System of South Korea from January 2019 to December 2020 were included in this study. We analyzed the clinical characteristics associated with TB and non-TB-related deaths, including TB-related symptoms, comorbidities, and radiographic and microbiological findings. Results: Of the total of 12,340 patients with TB, 61% were males with a mean age of 61.3 years. During the follow-up period, the overall mortality rate was 10.6%, with TB-related deaths accounting for 21.3% of all TB deaths. The median survival time in the TB-related death group was 22 days. TB-related death was associated with older age, lower body mass index (BMI), dyspnea, fever, general weakness, bilateral radiographic patterns, and acid-fast bacilli (AFB)-positive smears. Non-TB-related deaths were associated with older age, male sex, lower BMI, comorbidities of heart, liver, kidney, and central nervous system (CNS) diseases, CNS TB involvement, the presence of dyspnea, general weakness, and bilateral radiographic patterns. Conclusion: Patients with high-risk TB must be identified through cause-specific mortality analysis, and the mortality rate must be reduced through intensive monitoring of patients with a high TB burden and comorbidities.
KW - cause-specific mortality
KW - comorbididites
KW - death
KW - demographics
KW - symptom
KW - tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85171290691&partnerID=8YFLogxK
U2 - 10.3389/fpubh.2023.1207284
DO - 10.3389/fpubh.2023.1207284
M3 - Article
C2 - 37719730
AN - SCOPUS:85171290691
SN - 2296-2565
VL - 11
JO - Frontiers in Public Health
JF - Frontiers in Public Health
M1 - 1207284
ER -