D-tyrosine adds an anti-melanogenic effect to cosmetic peptides

Jisu Park, Hyejung Jung, Bohee Jang, Hyun Kuk Song, Inn Oc Han, Eok Soo Oh

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


D-tyrosine is known to negatively regulate melanin synthesis by inhibiting tyrosinase activity. Here, we further reveal that peptides containing terminal D-tyrosine can reduce the melanin contents of human melanocytes. The addition of D-tyrosine to the terminus of the commercial anti-wrinkle peptide, pentapeptide-18 endowed the peptide with the ability to reduce the melanin content and tyrosinase activity in human MNT-1 melanoma cells and primary melanocytes. Consistently, terminal D-tyrosine-containing pentapeptide-18 inhibited the melanogenesis induced by α-MSH treatment or UV irradiation of MNT-1 cells and reduced melanin synthesis in the epidermal basal layer of a 3D human skin model. Furthermore, the addition of D-tyrosine to an anti-aging peptide (GEKG) or an anti-inflammatory peptide (GHK) endowed these short peptides with anti-melanogenic effects without altering their intrinsic effects. Together, these data suggest that the addition of D-tyrosine at the terminus of a short cosmetic peptide adds an anti-melanogenic effect to its intrinsic cosmetic effect. Our work offers a novel means of generating dual-function cosmetic peptides.

Original languageEnglish
Article number262
JournalScientific Reports
Issue number1
StatePublished - 1 Dec 2020

Bibliographical note

Funding Information:
This work was supported by the Technology development Program (S2575938) funded by the Ministry of SMEs and Startups (MSS, Korea) and a part of the project titled ‘development of skin functional material using seaweed exosome’, funded by the Ministry of Oceans and Fisheries, Korea.

Publisher Copyright:
© 2020, The Author(s).


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