Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.

Dongyup Hahn, Dong Hwan Won, Bora Mun, Hiyoung Kim, Chulkyeong Han, Weihong Wang, Taeho Chun, Sunhee Park, Dajeong Yoon, Hyukjae Choi, Sang Jip Nam, Merrick Ekins, Jungwook Chin, Heonjoong Kang

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16 Scopus citations


Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23- hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23- hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.

Original languageEnglish
Pages (from-to)2336-2339
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number8
StatePublished - 15 Apr 2013

Bibliographical note

Funding Information:
D. Hahn, H. Kim, B. Mun, T. Chun, S. Park, and D. Yoon were in part supported by BK21 Program, the Ministry of Education, Science and Technology, Korea. This research was supported by Grants from the Marine Biotechnology Program funded by the Ministry of Land, Transport and Maritime Affairs of Korea.


  • Cytotoxicity
  • Pancreatic cancer cell lines
  • Psammocinia sp.
  • Renal cancer cell lines
  • Scalarane
  • Sesterterpenoid


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