Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.

Dongyup Hahn, Dong Hwan Won, Bora Mun, Hiyoung Kim, Chulkyeong Han, Weihong Wang, Taeho Chun, Sunhee Park, Dajeong Yoon, Hyukjae Choi, Sang Jip Nam, Merrick Ekins, Jungwook Chin, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23- hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23- hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.

Original languageEnglish
Pages (from-to)2336-2339
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number8
DOIs
StatePublished - 15 Apr 2013

Keywords

  • Cytotoxicity
  • Pancreatic cancer cell lines
  • Psammocinia sp.
  • Renal cancer cell lines
  • Scalarane
  • Sesterterpenoid

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