Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

Eun Kyoung Seo; Nam Cheol Kim; Mansukh C. Wani; Monroe E. Wall; Hernán A. Navarro; Jason P. Burgess; Kazuko Kawanishi; Leonardus B.S. Kardono; Soedarsono Riswan; William C. Rose; Craig R. Fairchild; Norman R. Farnsworth; A. Douglas Kinghorn

doi:10.1021/np010395f

Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

Eun Kyoung Seo
, Nam Cheol Kim
, Mansukh C. Wani
, Monroe E. Wall
, Hernán A. Navarro
, Jason P. Burgess
, Kazuko Kawanishi
, Leonardus B.S. Kardono
, Soedarsono Riswan
, William C. Rose
, Craig R. Fairchild
, Norman R. Farnsworth
, A. Douglas Kinghorn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and δ-tocotrienol, were obtained as inactive constituents.

Original language	English
Pages (from-to)	299-305
Number of pages	7
Journal	Journal of Natural Products
Volume	65
Issue number	3
DOIs	https://doi.org/10.1021/np010395f
State	Published - 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1021/np010395f

Cite this

Seo, E. K., Kim, N. C., Wani, M. C., Wall, M. E., Navarro, H. A., Burgess, J. P., Kawanishi, K., Kardono, L. B. S., Riswan, S., Rose, W. C., Fairchild, C. R., Farnsworth, N. R., & Kinghorn, A. D. (2002). Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum. Journal of Natural Products, 65(3), 299-305. https://doi.org/10.1021/np010395f

@article{7c9164bb1c6b465984138931ab1ea4e5,

title = "Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum",

abstract = "Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and δ-tocotrienol, were obtained as inactive constituents.",

author = "Seo, \{Eun Kyoung\} and Kim, \{Nam Cheol\} and Wani, \{Mansukh C.\} and Wall, \{Monroe E.\} and Navarro, \{Hern{\'a}n A.\} and Burgess, \{Jason P.\} and Kazuko Kawanishi and Kardono, \{Leonardus B.S.\} and Soedarsono Riswan and Rose, \{William C.\} and Fairchild, \{Craig R.\} and Farnsworth, \{Norman R.\} and Kinghorn, \{A. Douglas\}",

year = "2002",

doi = "10.1021/np010395f",

language = "English",

volume = "65",

pages = "299--305",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

AU - Seo, Eun Kyoung

AU - Kim, Nam Cheol

AU - Wani, Mansukh C.

AU - Wall, Monroe E.

AU - Navarro, Hernán A.

AU - Burgess, Jason P.

AU - Kawanishi, Kazuko

AU - Kardono, Leonardus B.S.

AU - Riswan, Soedarsono

AU - Rose, William C.

AU - Fairchild, Craig R.

AU - Farnsworth, Norman R.

AU - Kinghorn, A. Douglas

PY - 2002

Y1 - 2002

N2 - Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and δ-tocotrienol, were obtained as inactive constituents.

AB - Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and δ-tocotrienol, were obtained as inactive constituents.

UR - https://www.scopus.com/pages/publications/0036193526

U2 - 10.1021/np010395f

DO - 10.1021/np010395f

M3 - Article

C2 - 11908969

AN - SCOPUS:0036193526

SN - 0163-3864

VL - 65

SP - 299

EP - 305

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 3

ER -

Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this