Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

  • Eun Kyoung Seo
  • , Nam Cheol Kim
  • , Mansukh C. Wani
  • , Monroe E. Wall
  • , Hernán A. Navarro
  • , Jason P. Burgess
  • , Kazuko Kawanishi
  • , Leonardus B.S. Kardono
  • , Soedarsono Riswan
  • , William C. Rose
  • , Craig R. Fairchild
  • , Norman R. Farnsworth
  • , A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and δ-tocotrienol, were obtained as inactive constituents.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalJournal of Natural Products
Volume65
Issue number3
DOIs
StatePublished - 2002

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