Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

Eun Kyoung Seo, Nam Cheol Kim, Mansukh C. Wani, Monroe E. Wall, Hernán A. Navarro, Jason P. Burgess, Kazuko Kawanishi, Leonardus B.S. Kardono, Soedarsono Riswan, William C. Rose, Craig R. Fairchild, Norman R. Farnsworth, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and δ-tocotrienol, were obtained as inactive constituents.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalJournal of Natural Products
Volume65
Issue number3
DOIs
StatePublished - 2002

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