Cytotoxic prenylated flavanones from Monotes engleri

E. K. Seo, G. L. Silva, H. B. Chai, T. E. Chagwedera, N. R. Farnsworth, G. A. Cordell, J. M. Pezzuto, A. D. Kinghorn

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

From the leaves of Monotes engleri, five prenylated flavanones were isolated as constituents that displayed cytotoxic activity against several human cancer cell lines. Three of these substances are novel, namely, 6- (1,1-dimethylallyl)naringenin, 6-(1,1-dimethylallyl)eriodictyol and 3'-O- methyl-6-(1,1-dimethylallyl)-eriodictyol, with the other two active substances being the known flavanones, 6,8-diprenyleriodictyol and hiravanone. Additionally, two novel, but non-cytotoxic, biogenetically related flavanones were isolated, 6[(2RS)-hydroxy-3-methyl-3-butenyl]-8- prenyleriodictyol and 5,4'-dihydroxy-4''4''-dimethyl-5''-methyl-5''H- dihydrofurano[2''3'':6,7]flavanone. The structures of the new compounds were determined by spectral analysis 1D- and 2D-NMR experiments.

Original languageEnglish
Pages (from-to)509-515
Number of pages7
JournalPhytochemistry
Volume45
Issue number3
DOIs
StatePublished - Jun 1997

Keywords

  • cytotoxic activity
  • Dipterocarpaceae
  • human cancer cell lines
  • leaves
  • Monotes engleri
  • prenylated flavanones

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