Cytotoxic effects of quinoxaline derivatives on human cancer cell lines

Hee Won Yoo, Yun Sil Lee, Myung Eun Suh, Dong Jin Kim, Sang Woo Park

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The cytotoxicities of 6,7-modified-5,8-quinoxalinedione derivatives and heterocyclic quinoxaline derivatives containing nitrogen, sulfur, and oxygen on human lung adenocarcinoma cell (PC 14), human gastric adenocarcinoma cell (MKN 45), and human colon adenocarcinoma cell (colon 205) were examined in vitro using MTT assay. Pyrido[1,2-a]imidazo[4,5-g]quinoxaline-6,11-dione (10) was markedly cytotoxic against MKN 45 compared with adriamycin and cis- platin used as anticancer drugs. The IC50 value of compound 10 was 0.073 μM while those of adriamycin and cis-platin were 0.12 μM and 2.67 μM, respectively.

Original languageEnglish
Pages (from-to)331-333
Number of pages3
JournalArchiv der Pharmazie
Volume331
Issue number10
DOIs
StatePublished - Oct 1998

Keywords

  • 6,7-Modified-5,8-quinoxalinedione
  • Heterocyclic quinoxaline derivatives
  • Human gastric adenocarcinoma cell line

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