TY - JOUR
T1 - Cytotoxic effects of quinoxaline derivatives on human cancer cell lines
AU - Yoo, Hee Won
AU - Lee, Yun Sil
AU - Suh, Myung Eun
AU - Kim, Dong Jin
AU - Park, Sang Woo
PY - 1998/10
Y1 - 1998/10
N2 - The cytotoxicities of 6,7-modified-5,8-quinoxalinedione derivatives and heterocyclic quinoxaline derivatives containing nitrogen, sulfur, and oxygen on human lung adenocarcinoma cell (PC 14), human gastric adenocarcinoma cell (MKN 45), and human colon adenocarcinoma cell (colon 205) were examined in vitro using MTT assay. Pyrido[1,2-a]imidazo[4,5-g]quinoxaline-6,11-dione (10) was markedly cytotoxic against MKN 45 compared with adriamycin and cis- platin used as anticancer drugs. The IC50 value of compound 10 was 0.073 μM while those of adriamycin and cis-platin were 0.12 μM and 2.67 μM, respectively.
AB - The cytotoxicities of 6,7-modified-5,8-quinoxalinedione derivatives and heterocyclic quinoxaline derivatives containing nitrogen, sulfur, and oxygen on human lung adenocarcinoma cell (PC 14), human gastric adenocarcinoma cell (MKN 45), and human colon adenocarcinoma cell (colon 205) were examined in vitro using MTT assay. Pyrido[1,2-a]imidazo[4,5-g]quinoxaline-6,11-dione (10) was markedly cytotoxic against MKN 45 compared with adriamycin and cis- platin used as anticancer drugs. The IC50 value of compound 10 was 0.073 μM while those of adriamycin and cis-platin were 0.12 μM and 2.67 μM, respectively.
KW - 6,7-Modified-5,8-quinoxalinedione
KW - Heterocyclic quinoxaline derivatives
KW - Human gastric adenocarcinoma cell line
UR - http://www.scopus.com/inward/record.url?scp=0031726936&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1521-4184(199810)331:10<331::AID-ARDP331>3.3.CO;2-9
DO - 10.1002/(SICI)1521-4184(199810)331:10<331::AID-ARDP331>3.3.CO;2-9
M3 - Article
C2 - 9844581
AN - SCOPUS:0031726936
SN - 0365-6233
VL - 331
SP - 331
EP - 333
JO - Archiv der Pharmazie
JF - Archiv der Pharmazie
IS - 10
ER -