Cytotoxic constituents of the octocoral Dendronephthya gigantea

Ah Reum Han, Jun Im Song, Sik Jang Dae, Hye Young Min, Kook Lee Sang, Eun Kyoung Seo

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17 Scopus citations

Abstract

A known monoalkyl glycerol ether, (±)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalArchives of Pharmacal Research
Volume28
Issue number3
DOIs
StatePublished - 31 Mar 2005

Keywords

  • (2S, 3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol
  • (±)-1-Nonadecyloxy-2,3- propanediol
  • Cytotoxicity
  • Dendronephthya gigantea
  • Soft coral
  • Thymine
  • Uracil

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