Cytotoxic constituents of the octocoral Dendronephthya gigantea

Ah Reum Han; Jun Im Song; Sik Jang Dae; Hye Young Min; Kook Lee Sang; Eun Kyoung Seo

doi:10.1007/BF02977794

Cytotoxic constituents of the octocoral Dendronephthya gigantea

Ah Reum Han, Jun Im Song, Sik Jang Dae, Hye Young Min, Kook Lee Sang, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A known monoalkyl glycerol ether, (±)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.

Original language	English
Pages (from-to)	290-293
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	28
Issue number	3
DOIs	https://doi.org/10.1007/BF02977794
State	Published - 31 Mar 2005

Bibliographical note

Funding Information:
This investigation was supported by a Korea Research Foundation Grant (KRF-2003-005-E00003).

Keywords

(2S, 3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol
(±)-1-Nonadecyloxy-2,3- propanediol
Cytotoxicity
Dendronephthya gigantea
Soft coral
Thymine
Uracil

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02977794

Cite this

@article{c6b73a25ec34444cbc3ec70f0952003b,

title = "Cytotoxic constituents of the octocoral Dendronephthya gigantea",

abstract = "A known monoalkyl glycerol ether, (±)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.",

keywords = "(2S, 3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol, (±)-1-Nonadecyloxy-2,3- propanediol, Cytotoxicity, Dendronephthya gigantea, Soft coral, Thymine, Uracil",

author = "Han, {Ah Reum} and Song, {Jun Im} and Dae, {Sik Jang} and Min, {Hye Young} and Sang, {Kook Lee} and Seo, {Eun Kyoung}",

note = "Funding Information: This investigation was supported by a Korea Research Foundation Grant (KRF-2003-005-E00003).",

year = "2005",

month = mar,

day = "31",

doi = "10.1007/BF02977794",

language = "English",

volume = "28",

pages = "290--293",

journal = "Archives of Pharmacal Research",

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publisher = "Pharmaceutical Society of Korea",

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}

TY - JOUR

T1 - Cytotoxic constituents of the octocoral Dendronephthya gigantea

AU - Han, Ah Reum

AU - Song, Jun Im

AU - Dae, Sik Jang

AU - Min, Hye Young

AU - Sang, Kook Lee

AU - Seo, Eun Kyoung

N1 - Funding Information: This investigation was supported by a Korea Research Foundation Grant (KRF-2003-005-E00003).

PY - 2005/3/31

Y1 - 2005/3/31

N2 - A known monoalkyl glycerol ether, (±)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.

AB - A known monoalkyl glycerol ether, (±)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.

KW - (2S, 3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol

KW - (±)-1-Nonadecyloxy-2,3- propanediol

KW - Cytotoxicity

KW - Dendronephthya gigantea

KW - Soft coral

KW - Thymine

KW - Uracil

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DO - 10.1007/BF02977794

M3 - Article

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AN - SCOPUS:23344433105

SN - 0253-6269

VL - 28

SP - 290

EP - 293

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 3

ER -

Cytotoxic constituents of the octocoral Dendronephthya gigantea

Abstract

Bibliographical note

Keywords

UN SDGs

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